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Mouse Anti-FOXC2 (AA 156-256) Recombinant Antibody (CBXF-3140) (CBMAB-F3836-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3140
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
FOXC2 (NP_005242, 156aa-256aa) full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 156-256

Target

Full Name
FOXC2
Introduction
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.
Entrez Gene ID
2303
UniProt ID
Q99958
Alternative Names
Forkhead Box C2; Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1); Forkhead-Related Protein FKHL14; Mesenchyme Fork Head Protein 1; Transcription Factor FKH-14; Mesenchyme Forkhead 1; FKHL14; MFH1;
Function
Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Artery morphogenesis Source: Ensembl
Blood vessel diameter maintenance Source: Ensembl
Blood vessel remodeling Source: Ensembl
Branching involved in blood vessel morphogenesis Source: Ensembl
Camera-type eye development Source: Ensembl
Cardiac muscle cell proliferation Source: Ensembl
Cell differentiation Source: GO_Central
Collagen fibril organization Source: Ensembl
Embryonic heart tube development Source: Ensembl
Embryonic viscerocranium morphogenesis Source: Ensembl
Glomerular endothelium development Source: Ensembl
Glomerular mesangial cell development Source: Ensembl
Glomerular visceral epithelial cell differentiation Source: Ensembl
Heart development Source: DFLAT
Insulin receptor signaling pathway Source: UniProtKB
Lymphangiogenesis Source: UniProtKB
Mesoderm development Source: UniProtKB
Metanephros development Source: Ensembl
Negative regulation of apoptotic process involved in outflow tract morphogenesis Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Neural crest cell development Source: Ensembl
Notch signaling pathway Source: Ensembl
Ossification Source: Ensembl
Paraxial mesodermal cell fate commitment Source: Ensembl
Positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of endothelial cell migration Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of vascular wound healing Source: BHF-UCL
Regulation of organ growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to hormone Source: UniProtKB
Somitogenesis Source: Ensembl
Ureteric bud development Source: Ensembl
Vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Lymphedema-distichiasis syndrome (LPHDST):
An autosomal dominant disorder characterized by primary limb lymphedema associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices). Swelling of the extremities, due to altered lymphatic flow, usually appears in late childhood or puberty. Most affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia. Drooping of the upper eyelid (ptosis) is a variable feature of the lymphedema-distichiasis syndrome, occurring in about 30% of patients.
PTM
Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.
More Infomation

Hargadon, K. M., Goodloe III, T. B., & Lloyd, N. D. (2022). Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective. Cancer and Metastasis Reviews, 1-20.

González-Loyola, A., Bovay, E., Kim, J., Lozano, T. W., Sabine, A., Renevey, F., ... & Petrova, T. V. (2021). FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure. Science Advances, 7(29), eabf4335.

Shen, X., Zhao, K., Xu, L., Cheng, G., Zhu, J., Gan, L., ... & Zhuang, Z. (2021). YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway. Frontiers in Genetics, 11, 592042.

Yan, J., Liu, J., Huang, Z., Huang, W., & Lv, J. (2021). FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells. Human Cell, 34(6), 1755-1764.

Pan, K., & Xie, Y. (2020). LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca2+-FAK signal pathway. Cell death & disease, 11(6), 434.

Norden, P. R., Sabine, A., Wang, Y., Demir, C. S., Liu, T., Petrova, T. V., & Kume, T. (2020). Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation. Elife, 9, e53814.

Yan, M., Gao, H., Lv, Z., Liu, Y., Zhao, S., Gong, W., & Liu, W. (2020). Circular RNA PVT1 promotes metastasis via regulating of miR‐526b/FOXC2 signals in OS cells. Journal of cellular and molecular medicine, 24(10), 5593-5604.

Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., ... & Chen, Y. (2019). Structural basis for DNA recognition by FOXC2. Nucleic acids research, 47(7), 3752-3764.

Børretzen, A., Gravdal, K., Haukaas, S. A., Beisland, C., Akslen, L. A., & Halvorsen, O. J. (2019). FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer. The Journal of Pathology: Clinical Research, 5(4), 272-286.

Wang, T., Zheng, L., Wang, Q., & Hu, Y. W. (2018). Emerging roles and mechanisms of FOXC2 in cancer. Clinica Chimica Acta, 479, 84-93.

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For research use only. Not intended for any clinical use.

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