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Mouse Anti-FOXA3 Recombinant Antibody (CBXF-3136) (CBMAB-F3832-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3136
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa266-350 from human FOXA3 (NP_004488.2) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FOXA3
Introduction
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
Entrez Gene ID
3171
UniProt ID
P55318
Alternative Names
Forkhead Box A3; Fork Head-Related Protein FKH H3; Forkhead Box Protein A3; Transcription Factor 3G; HNF-3-Gamma; HNF-3G; TCF-3G;
Function
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity).

Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Cellular glucose homeostasis Source: UniProtKB
Cellular response to starvation Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Hematopoietic stem cell homeostasis Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: UniProtKB-KW
Cellular Location
Nucleus
More Infomation

Walker, C., Boisvert, A., Malusare, P., & Culty, M. (2023). Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes. International Journal of Molecular Sciences, 24(2), 1211.

Wang, L., Li, B., Bo, X., Yi, X., Xiao, X., & Zheng, Q. (2022). Hypoxia-induced LncRNA DACT3-AS1 upregulates PKM2 to promote metastasis in hepatocellular carcinoma through the HDAC2/FOXA3 pathway. Experimental & Molecular Medicine, 54(6), 848-860.

Zheng, B., Seltzsam, S., Wang, C., Schierbaum, L., Schneider, S., Wu, C. H. W., ... & Hildebrandt, F. (2022). Whole-exome sequencing identifies FOXL2, FOXA2 and FOXA3 as candidate genes for monogenic congenital anomalies of the kidneys and urinary tract. Nephrology Dialysis Transplantation, 37(10), 1833-1843.

Vargas-Alarcón, G., Fragoso, J. M., Ramírez-Bello, J., & Posadas-Sánchez, R. (2022). FOXA3 Polymorphisms Are Associated with Metabolic Parameters in Individuals with Subclinical Atherosclerosis and Healthy Controls—The GEA Mexican Study. Biomolecules, 12(5), 601.

Zhan, X., & Zhao, A. (2021). Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression. Journal of clinical laboratory analysis, 35(3), e23686.

Liu, C., Zhou, B., Meng, M., Zhao, W., Wang, D., Yuan, Y., ... & Lu, Y. (2021). FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. Journal of Hepatology, 75(1), 150-162.

Kim, H., Kumar, S., & Lee, K. (2021). FOXA3, a negative regulator of Nur77 expression and activity in testicular steroidogenesis. International Journal of Endocrinology, 2021.

Li, N., Li, Y., Gao, H., Li, J., Ma, X., Liu, X., ... & Li, Y. (2021). Forkhead-box A3 (FOXA3) represses cancer stemness and partially potentiates chemosensitivity by targeting metastasis-associated in colon cancer 1 (MACC1) signaling pathway in colorectal cancer cells. Current Cancer Drug Targets, 21(3), 254-267.

Liu, Q., Li, H., Wang, J., Zhong, L., Chen, X., Zhang, R., & Wang, H. (2020). Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway. Experimental Gerontology, 139, 111053.

Thanan, R., Kaewlert, W., Sakonsinsiri, C., Chaiprasert, T., Armartmuntree, N., Muengsaen, D., ... & Pairojkul, C. (2020). Opposing roles of FoxA1 and FoxA3 in intrahepatic cholangiocarcinoma progression. International Journal of Molecular Sciences, 21(5), 1796.

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For research use only. Not intended for any clinical use.

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