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Mouse Anti-FOSB (AA 1-255) Recombinant Antibody (CBXF-3593) (CBMAB-F2522-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3593
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-255

Target

Full Name
FOSB
Introduction
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
2354
UniProt ID
P53539
Alternative Names
FosB Proto-Oncogene, AP-1 Transcription Factor Subunit; FBJ Murine Osteosarcoma Viral Oncogene Homolog B; G0/G1 Switch Regulatory Protein 3; Activator Protein 1; G0S3; FosB Proto-Oncogene, AP-1 Trancription Factor Subunit;
Function
FosB interacts with Jun proteins enhancing their DNA binding activity.
Biological Process
Cellular response to calcium ion Source: Ensembl
Cellular response to hormone stimulus Source: Ensembl
Female pregnancy Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to cAMP Source: Ensembl
Response to corticosterone Source: Ensembl
Response to drug Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to morphine Source: Ensembl
Response to progesterone Source: Ensembl
Transcription by RNA polymerase II Source: Ensembl
Cellular Location
Nucleus
More Infomation

Tsuda, Y., Suurmeijer, A. J., Sung, Y. S., Zhang, L., Healey, J. H., & Antonescu, C. R. (2021). Epithelioid hemangioma of bone harboring FOS and FOSB gene rearrangements: a clinicopathologic and molecular study. Genes, Chromosomes and Cancer, 60(1), 17-25.

Bridge, J. A., Sumegi, J., Royce, T., Baker, M., & Linos, K. (2021). A novel CLTC‐FOSB gene fusion in pseudomyogenic hemangioendothelioma of bone. Genes, Chromosomes and Cancer, 60(1), 38-42.

Zhang, R., Li, X., Liu, Z., Wang, Y., Zhang, H., & Xu, H. (2020). EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progress. Cancer Cell International, 20(1), 1-11.

Zhu, G., Benayed, R., Ho, C., Mullaney, K., Sukhadia, P., Rios, K., ... & Hameed, M. R. (2019). Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma. Modern Pathology, 32(5), 609-620.

Panagopoulos, I., Lobmaier, I., Gorunova, L., & Heim, S. (2019). Fusion of the genes WWTR1 and FOSB in pseudomyogenic hemangioendothelioma. Cancer Genomics & Proteomics, 16(4), 293-298.

Park, J. A., Na, H. H., Jin, H. O., & Kim, K. C. (2019). Increased expression of fosb through reactive oxygen species accumulation functions as pro-apoptotic protein in Piperlongumine Treated MCF7 breast cancer cells. Molecules and cells, 42(12), 884.

Gajewski, P. A., Eagle, A. L., Williams, E. S., Manning, C. E., Lynch, H., McCornack, C., ... & Robison, A. J. (2019). Epigenetic regulation of hippocampal fosb expression controls behavioral responses to cocaine. Journal of Neuroscience, 39(42), 8305-8314.

Agaram, N. P., Zhang, L., Cotzia, P., & Antonescu, C. R. (2018). Expanding the spectrum of genetic alterations in pseudomyogenic hemangioendothelioma with recurrent novel ACTB-FOSB gene fusions. The American journal of surgical pathology, 42(12), 1653.

Hamilton, P. J., Burek, D. J., Lombroso, S. I., Neve, R. L., Robison, A. J., Nestler, E. J., & Heller, E. A. (2018). Cell-type-specific epigenetic editing at the Fosb gene controls susceptibility to social defeat stress. Neuropsychopharmacology, 43(2), 272-284.

Fittall, M. W., Mifsud, W., Pillay, N., Ye, H., Strobl, A. C., Verfaillie, A., ... & Behjati, S. (2018). Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nature communications, 9(1), 2150.

Liu, S., Luan, J., & Ding, Y. (2018). miR-144-3p targets FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) to suppress proliferation, migration, and invasion of PANC-1 pancreatic cancer cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 26(5), 683-690.

Ortins‐Pina, A., Llamas‐Velasco, M., Turpin, S., Soares‐de‐Almeida, L., Filipe, P., & Kutzner, H. (2018). FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia). Journal of Cutaneous Pathology, 45(6), 395-402.

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For research use only. Not intended for any clinical use.

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