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Mouse Anti-FKBPL Recombinant Antibody (170) (CBMAB-AP2306LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
170
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Fusion protein of FKBPL
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FK506 Binding Protein Like
Introduction
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human63943
Mouse56299
UniProt ID
HumanQ9UIM3
MouseO35450
Alternative Names
FK506 Binding Protein Like; WAF-1/CIP1 Stabilizing Protein 39; WISP39; DIR1; NG7; Peptidyl-Prolyl Cis-Trans Isomerase; FK506-Binding Protein Like; FK506-Binding Protein-Like; FKBP4;
Function
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
Biological Process
Regulation of blood vessel branching Source: Ensembl
Response to radiation Source: UniProtKB
Cellular Location
Cytosol; Extracellular region
More Infomation

Ghorbanpour, S. M., Richards, C., Pienaar, D., Sesperez, K., Aboulkheyr Es, H., Nikolic, V. N., ... & McClements, L. (2023). A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia. Cellular and Molecular Life Sciences, 80(2), 44.

Obradović, D. D., Milić, N. M., Miladinović, N., McClements, L., & Oprić, D. M. (2022). Loss of Expression of Antiangiogenic Protein FKBPL in Endometrioid Endometrial Carcinoma: Implications for Clinical Practice. Medicina, 58(10), 1330.

Kim, H., Han, G. H., Yun, H., Kim, J. H., & Cho, H. (2022). EP238/# 618 High FKBPL expression contributes to cell proliferation by regulating the cell cycle and affects prognosis in ovarian cancer patients.

Annett, S., Spence, S., Garciarena, C., Campbell, C., Dennehy, M., Drakeford, C., ... & Robson, T. (2021). The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-κB signaling. bioRxiv, 2021-02.

Todd, N., McNally, R., Alqudah, A., Jerotic, D., Suvakov, S., Obradovic, D., ... & McClements, L. (2021). Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment. The Journal of Clinical Endocrinology & Metabolism, 106(1), 26-41.

Alqudah, A., Eastwood, K. A., Jerotic, D., Todd, N., Hoch, D., McNally, R., ... & McClements, L. (2021). FKBPL and SIRT-1 are downregulated by diabetes in pregnancy impacting on angiogenesis and endothelial function. Frontiers in endocrinology, 459.

Akyuz Sengun, D., Guzel Tanoglu, E., & Ulucan, H. (2021). A novel mutation in FK506 binding protein-like (FKBPL) causes male infertility. Croatian Medical Journal, 62(3), 227-232.

Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., ... & Robson, T. (2020). FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer. British Journal of Cancer, 122(3), 361-371.

Januszewski, A. S., Watson, C. J., O’Neill, V., McDonald, K., Ledwidge, M., Robson, T., ... & McClements, L. (2020). FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease. Scientific Reports, 10(1), 1-7.

McClements, L., Annett, S., Yakkundi, A., O’Rourke, M., Valentine, A., Moustafa, N., ... & Robson, T. (2019). FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4. BMC cancer, 19, 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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