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Mouse Anti-FBLN2 Antibody (1D8) (CBMAB-0052-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D8
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibulin 2
Introduction
Fibulin 2 (FBLN2) is an extracellular matrix protein, which belongs to the fibulin family. FBLN2 has been shown to interact with Laminin, alpha 1, Laminin, alpha 5 and Perlecan. And it may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures.
Entrez Gene ID
2199
UniProt ID
P98095
Alternative Names
FBLN2; Fibulin 2; FIBL-2; 5730577E14Rik
Research Area
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Biological Process
Extracellular matrix organization Source: InterPro
Positive regulation of cell-substrate adhesion Source: GO_Central
Cellular Location
Extracellular matrix
PTM
O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.
More Infomation

Balog, S., Fujiwara, R., Pan, S. Q., El‐Baradie, K. B., Choi, H. Y., Sinha, S., ... & Tsukamoto, H. (2022). Emergence of highly profibrotic and proinflammatory Lrat+ Fbln2+ HSC subpopulation in alcoholic hepatitis. Hepatology.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Correction to: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Medicine, 13.

Shen, Z., & Li, H. (2021). Long non-coding RNA GAS5 knockdown facilitates proliferation and impedes apoptosis by regulating miR-128-3p/FBLN2 axis in ox-LDL-induced THP-1 cells. Clinical Hemorheology and Microcirculation, 77(2), 153-164.

Zhu, N., Swietlik, E. M., Welch, C. L., Pauciulo, M. W., Hagen, J. J., Zhou, X., ... & Chung, W. K. (2021). Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome medicine, 13(1), 1-18.

Vaes, N., Schonkeren, S. L., Rademakers, G., Holland, A. M., Koch, A., Gijbels, M. J., ... & Melotte, V. (2021). Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO reports, 22(6), e51913.

Li, W. M., Chan, T. C., Huang, S. K. H., Wu, W. J., Ke, H. L., Liang, P. I., ... & Li, C. F. (2020). Prognostic utility of FBLN2 expression in patients with urothelial carcinoma. Frontiers in Oncology, 10, 570340.

Tang, C. Z., Yang, J. T., Liu, Q. H., Wang, Y. R., & Wang, W. S. (2019). Up‐regulated miR‐192‐5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2‐mediated TGF‐β1 signaling pathway. The FASEB Journal, 33(1), 606-618.

Davila, N., Hernandez, L. F., Corredor, C., Perez-Vazquez, J. F. F., Soberón, S., Enriquez, A., ... & Quiroz-Mercado, H. (2018). Expression levels of Fibulin-2 (Fbln2) and Fibulin-5 (Fbln5) on subretinal fluid in human primary rhegmatogenous retinal detachment. Investigative Ophthalmology & Visual Science, 59(9), 4225-4225.

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For research use only. Not intended for any clinical use.

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