Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-FANCG (AA 1-623) Recombinant Antibody (CBXF-0292) (CBMAB-F0277-CQ)


See all FANCG antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0292
Antibody Isotype
IgG2a
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-623

Target

Full Name
Fanconi anemia, complementation group G
Introduction
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.
Entrez Gene ID
2189
UniProt ID
O15287
Alternative Names
Fanconi Anemia Complementation Group G; DNA Repair Protein XRCC9; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 9; X-Ray Repair, Complementing Defective, In Chinese Hamster, 9; XRCC9; Truncated Fanconi Anemia Group G Protein; Fanconi Anemia Group G Protein; Protein FACG; FAG;
Research Area
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Biological Process
Cellular response to DNA damage stimulus Source: GO_Central
DNA repair Source: ProtInc
Interstrand cross-link repair Source: InterPro
Mitochondrion organization Source: UniProtKB
Ovarian follicle development Source: Ensembl
Response to radiation Source: Ensembl
Spermatid development Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. The major form is nuclear. The minor form is cytoplasmic.
Involvement in disease
Fanconi anemia complementation group G (FANCG):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
More Infomation

Reyes, P., García-de Teresa, B., Juárez, U., Pérez-Villatoro, F., Fiesco-Roa, M. O., Rodríguez, A., ... & Frias, S. (2022). Fanconi anemia patients from an indigenous community in Mexico carry a new founder pathogenic variant in FANCG. International journal of molecular sciences, 23(4), 2334.

Meek, K., Yang, Y. T., Takada, M., Parys, M., Richter, M., Engleberg, A. I., ... & Yuzbasiyan-Gurkan, V. (2022). Identification of a Hypomorphic FANCG Variant in Bernese Mountain Dogs. Genes, 13(10), 1693.

Shahid, M., Azfaralariff, A., Zubair, M., Najm, A. A., Khalili, N., Law, D., ... & Fazry, S. (2022). In silico study of missense variants of FANCA, FANCC and FANCG genes reveals high risk deleterious alleles predisposing to Fanconi anemia pathogenesis. Gene, 812, 146104.

Farah, R. A., Nair, P., Koueik, J., Yammine, T., Khalifeh, H., Korban, R., ... & Megarbane, A. (2021). Clinical and Genetic Features of Patients with Fanconi Anemia in Lebanon and Report on Novel Mutations in the FANCA and FANCG Genes. Journal of Pediatric Hematology/Oncology, 43(5), e727-e735.

Jeong, E., Lee, S. G., Kim, H. S., Yang, J., Shin, J., Kim, Y., ... & Cho, Y. (2020). Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex. Nucleic acids research, 48(6), 3328-3342.

Kapoor, B. S., Mandal, K., Ghosh, S., Mokhamatam, R. B., Manna, S. K., & Mukhopadhyay, S. S. (2020). Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase. Molecular and cellular biology, 40(23).

Dillon, B., Feben, C., Segal, D., Du Plessis, J., Reynders, D., Wainwright, R., ... & Krause, A. (2020). Endocrine profiling in patients with Fanconi anemia, homozygous for a FANCG founder mutation. Molecular Genetics & Genomic Medicine, 8(8), e1351.

Zha, J., Kunselman, L., Fan, J. M., & Olson, T. S. (2019). Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells after transplantation. haematologica, 104(7), e284.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FANCG (AA 1-623) Recombinant Antibody (CBXF-0292)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry