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Mouse Anti-FABP5 Recombinant Antibody (28) (CBMAB-F2748-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
28
Antibody Isotype
IgG1
Application
WB, IA, S-ELISA

Basic Information

Immunogen
Human heart FABP
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fatty Acid Binding Protein 5
Introduction
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.
Entrez Gene ID
2171
UniProt ID
Q01469
Alternative Names
Fatty Acid Binding Protein 5; Psoriasis-Associated Fatty Acid-Binding Protein Homolog; Fatty Acid Binding Protein 5 (Psoriasis-Associated); Epidermal-Type Fatty Acid-Binding Protein; PA-FABP; E-FABP;
Research Area
Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585).

Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).

May be involved in keratinocyte differentiation (PubMed:8092987).
Biological Process
Epidermis development Source: ProtInc
Glucose homeostasis Source: Ensembl
Glucose metabolic process Source: Ensembl
Lipid metabolic process Source: ProtInc
Lipid transport across blood-brain barrier Source: ARUK-UCL
Long-chain fatty acid transport Source: ARUK-UCL
Negative regulation of glucose transmembrane transport Source: Ensembl
Phosphatidylcholine biosynthetic process Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of peroxisome proliferator activated receptor signaling pathway Source: Ensembl
Regulation of prostaglandin biosynthetic process Source: Ensembl
Regulation of retrograde trans-synaptic signaling by endocanabinoid Source: UniProtKB
Regulation of sensory perception of pain Source: Ensembl
Cellular Location
Secreted; Cytoplasm; Nucleus; Synapse; Postsynaptic density. Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).
More Infomation

Li, R., Liang, Y., & Lin, B. (2022). Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF‐κB signaling pathway in the retina of aged mice. Aging Cell, 21(3), e13566.

Wang, W., Liu, Z., Chen, X., Lu, Y., Wang, B., Li, F., ... & Zhou, X. (2021). Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway. DNA and Cell Biology, 40(8), 1076-1086.

Guo, Y., Liu, Y., Zhao, S., Xu, W., Li, Y., Zhao, P., ... & Zhang, X. (2021). Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages. Nature Communications, 12(1), 1-18.

Seo, J., Jeong, D. W., Park, J. W., Lee, K. W., Fukuda, J., & Chun, Y. S. (2020). Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Communications biology, 3(1), 1-14.

O'Sullivan, S. E., & Kaczocha, M. (2020). FABP5 as a novel molecular target in prostate cancer. Drug discovery today, 25(11), 2056-2061.

Zhang, C., Liao, Y., Liu, P., Du, Q., Liang, Y., Ooi, S., ... & Wang, W. (2020). FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Theranostics, 10(15), 6561.

Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2020). Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free energy analyses. Physical Chemistry Chemical Physics, 22(4), 2262-2275.

Liu, F., Liu, W., Zhou, S., Yang, C., Tian, M., Jia, G., ... & Wu, D. (2020). Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma. Journal for immunotherapy of cancer, 8(2).

Carbonetti, G., Wilpshaar, T., Kroonen, J., Studholme, K., Converso, C., d’Oelsnitz, S., & Kaczocha, M. (2019). FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Scientific reports, 9(1), 1-16.

Lv, Q., Wang, G., Zhang, Y., Han, X., Li, H., Le, W., ... & Ding, Q. (2019). FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. International Journal of Oncology, 54(4), 1221-1232.

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For research use only. Not intended for any clinical use.

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