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Mouse Anti-F3 Recombinant Antibody (HTF-1) (CBMAB-C1775-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
HTF-1
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coagulation Factor III, Tissue Factor
Introduction
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
2152
UniProt ID
P13726
Alternative Names
Coagulation Factor III, Tissue Factor; Coagulation Factor III (Thromboplastin, Tissue Factor); Tissue Factor; TF; Coagulation Factor III; Thromboplastin; CD142 Antigen; CD142; TFA;
Research Area
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Biological Process
Activation of blood coagulation via clotting cascade Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
Blood coagulation Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Protein processing Source: BHF-UCL
Cellular Location
Isoform 1: Membrane
Isoform 2: Secreted
Topology
Extracellular: 33-251
Helical: 252-274
Cytoplasmic: 275-295
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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