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Rabbit Anti-F3 Recombinant Antibody (CBYJT-1268) (CBMAB-T0283-YJ)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYJT-1268
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Mouse Coagulation Factor III / Tissue Factor / CD142 / F3 Protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coagulation Factor III, Tissue Factor
Introduction
F3 initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Entrez Gene ID
14066
UniProt ID
P20352
Alternative Names
TF; Cf3; Cf-3; CD142; AA409063
Research Area
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Biological Process
Activation of blood coagulation via clotting cascade Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Activation of plasma proteins involved in acute inflammatory response Source: BHF-UCL
Blood coagulation Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Protein processing Source: BHF-UCL
Cellular Location
Isoform 1: Membrane
Isoform 2: Secreted
Topology
Extracellular: 33-251
Helical: 252-274
Cytoplasmic: 275-295
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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