Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-ESRP2 Recombinant Antibody (23A7.C9) (CBMAB-E1896-FY)


See all ESRP2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
23A7.C9
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Anti-Esrp-1/2 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ESRP2
Introduction
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009).
Entrez Gene ID
77411
UniProt ID
Q8K0G8
Alternative Names
Rbm35b; 9530027K23Rik
Research Area
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Biological Process
Alternative mRNA splicing, via spliceosome Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Regulation of RNA splicing Source: UniProtKB
Cellular Location
Nucleus
More Infomation

Shen, D., Ding, L., Lu, Z., Wang, R., Yu, C., Wang, H., ... & Li, G. (2022). METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination. Molecular Therapy-Nucleic Acids, 27, 547-561.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2022). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. Molecular oncology, 16(3), 630-647.

Hyun, J., Al Abo, M., Dutta, R. K., Oh, S. H., Xiang, K., Zhou, X., ... & Diehl, A. M. (2021). Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. Journal of Hepatology, 75(3), 623-633.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2021). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. bioRxiv, 2020-11.

Becker, T., Pich, A., Tamm, S., Hedtfeld, S., Ibrahim, M., Altmüller, J., ... & Stanke, F. (2020). Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. Scientific reports, 10(1), 1-19.

Yue, P. J., Sun, Y. Y., Li, Y. H., Xu, Z. M., & Fu, W. N. (2020). MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway. Cellular Signalling, 74, 109709.

Freytag, M., Kluth, M., Bady, E., Hube-Magg, C., Makrypidi-Fraune, G., Heinzer, H., ... & Möller, K. (2020). Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer. BMC cancer, 20(1), 1-12.

Munkley, J., Li, L., Krishnan, S. G., Hysenaj, G., Scott, E., Dalgliesh, C., ... & Elliott, D. J. (2019). Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife, 8.

Lu, G., Duan, J., & Zhou, D. (2018). Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas. Pathology-Research and Practice, 214(12), 2054-2061.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ESRP2 Recombinant Antibody (23A7.C9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry