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Rat Anti-EPHA7 Monoclonal Antibody (6E1) (CBMAB-1174-YC)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
6E1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant mouse EphA7 extracellular domain
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EPH Receptor A7
Introduction
EPHA7 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of EPHA7 gene is associated with multiple forms of carcinoma.
Entrez Gene ID
13841
UniProt ID
Q61772
Alternative Names
EHK3; EK11; EHK-3; HEK11
Research Area
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Biological Process
Apoptotic process Source: UniProtKB-KW
Axon guidance Source: GO_Central
Brain development Source: UniProtKB
Branching morphogenesis of a nerve Source: UniProtKB
Ephrin receptor signaling pathway Source: UniProtKB
Negative chemotaxis Source: UniProtKB
Negative regulation of collateral sprouting Source: Ensembl
Negative regulation of synapse assembly Source: Ensembl
Nephric duct morphogenesis Source: Ensembl
Phosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Positive regulation of neuron apoptotic process Source: UniProtKB
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Regulation of postsynapse organization Source: Ensembl
Regulation of protein autophosphorylation Source: UniProtKB
Retinal ganglion cell axon guidance Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 28-555
Helical: 556-576
Cytoplasmic: 577-998
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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