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Mouse Anti-EP400 (AA 743-851) Recombinant Antibody (CBFYE-0227) (CBMAB-E0477-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0227
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant from human EP400 with GST tag MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 743-851

Target

Full Name
E1A binding protein p400
Introduction
EP400 (E1A Binding Protein P400) is a Protein Coding gene. Diseases associated with EP400 include Ossifying Fibromyxoid Tumor. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is SRCAP.
Entrez Gene ID
57634
UniProt ID
Q96L91
Alternative Names
E1A Binding Protein P400; Trinucleotide Repeat-Containing Gene 12 Protein; Trinucleotide Repeat Containing 12; P400 KDa SWI2/SNF2-Related Protein; CAG Repeat Protein 32; Domino Homolog; HDomino; TNRC12; CAGH32
Research Area
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Biological Process
Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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