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Mouse Anti-ENKUR Recombinant Antibody (3B3) (CBMAB-A0919-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
C10orf63 (NP_659447.1, 1 a.a. ~ 256 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Enkurin, TRPC Channel Interacting Protein
Introduction
Enkurin interacts with transient receptor potential canonical (TRPC) cation channels (see TRPC1; MIM 602343) and functions as an adaptor protein, tethering signal transduction proteins to TRPC channels (Sutton et al., 2004 [PubMed 15385169]).[supplied by OMIM
Entrez Gene ID
219670
UniProt ID
Q8TC29
Alternative Names
DKFZp781F21103; MGC26778
Research Area
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.
Biological Process
Establishment of left/right asymmetry Source: GO_Central
Flagellated sperm motility Source: Ensembl
Cellular Location
Flagellum. Sperm acrosomal crescent and flagellar principal piece.
More Infomation

Liu, J. H., Yang, H. L., Deng, S. T., Hu, Z., Chen, W. F., Yan, W. W., ... & Fang, W. Y. (2022). The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma. Acta Pharmacologica Sinica, 1-9.

Hou, R., Li, Y., Luo, X., Zhang, W., Yang, H., Zhang, Y., ... & Fang, W. (2022). ENKUR expression induced by chemically synthesized cinobufotalin suppresses malignant activities of hepatocellular carcinoma by modulating β-catenin/c-Jun/MYH9/USP7/c-Myc axis. International journal of biological sciences, 18(6), 2553.

Hou, R., Liu, X., Yang, H., Deng, S., Cheng, C., Liu, J., ... & Fang, W. (2022). Chemically synthesized cinobufagin suppresses nasopharyngeal carcinoma metastasis by inducing ENKUR to stabilize p53 expression. Cancer Letters, 531, 57-70.

Hou, R., Liu, X., Yang, H., Chen, C., Liu, J., Li, Y., ... & Fang, W. Y. (2021). Cinobufotalin, a Small Chemical Drug, Suppresses Nasopharyngeal Carcinoma Metastasis by Inducing ENKUR to Depress β-Catenin/C-Jun/MYH9 Signal-Mediated p53 Ubiquitination.

Ma, Q., Lu, Y., Lin, J., & Gu, Y. (2019). ENKUR acts as a tumor suppressor in lung adenocarcinoma cells through PI3K/Akt and MAPK/ERK signaling pathways. Journal of Cancer, 10(17), 3975.

Ma, Q., Lu, Y., & Gu, Y. (2019). ENKUR is involved in the regulation of cellular biology in colorectal cancer cells via PI3K/Akt signaling pathway. Technology in Cancer Research & Treatment, 18, 1533033819841433.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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