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Mouse Anti-EMP3 (AA 1-163) Recombinant Antibody (CBFYE-0100) (CBMAB-E0207-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0100
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human EMP3, Met1-Glu163
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-163

Target

Full Name
epithelial membrane protein 3
Introduction
The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
2014
UniProt ID
P54852
Alternative Names
Epithelial Membrane Protein 3; Hematopoietic Neural Membrane Protein 1; HNMP-1; EMP-3; YMP; Protein YMP
Research Area
Probably involved in cell proliferation and cell-cell interactions.
Biological Process
Bleb assembly Source: UniProtKB
Cell death Source: UniProtKB
Cellular Location
Membrane
More Infomation

Chen, Q., Jin, J., Huang, X., Wu, F., Huang, H., & Zhan, R. (2021). EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion. Journal of Experimental & Clinical Cancer Research, 40(1), 1-13.

Kahm, Y. J., Kim, R. K., Jung, U., & Kim, I. G. (2021). Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF‑β signaling pathway. International Journal of Oncology, 59(4), 1-9.

Martija, A. A., & Pusch, S. (2021). The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. International Journal of Molecular Sciences, 22(10), 5261.

Zhou, K., Sun, Y., Dong, D., Zhao, C., & Wang, W. (2021). EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell death & disease, 12(9), 1-10.

Li, S., Peng, H., & Li, J. (2020). MiR-765 Regulates Breast Cancer Cell Proliferation, Apoptosis, and Adriamycin Resistance Through Targeting Epithelial Membrane Protein 3. Journal of Biomaterials and Tissue Engineering, 10(8), 1193-1198.

Christians, A., Poisel, E., Hartmann, C., von Deimling, A., & Pusch, S. (2019). Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. International journal of cancer, 145(2), 461-473.

Ma, Q., Zhang, Y., Liang, H., Zhang, F., Liu, F., Chen, S., ... & Liu, Y. (2018). EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer letters, 430, 97-108.

Kusumoto, Y., Okuyama, H., Shibata, T., Konno, K., Takemoto, Y., Maekawa, D., ... & Tomura, M. (2018). Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Cellular Immunology, 324, 33-41.

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For research use only. Not intended for any clinical use.

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