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Mouse Anti-EMILIN1 Recombinant Antibody (320) (CBMAB-AP2055LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
320
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of EMILIN1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Elastin Microfibril Interfacer 1
Introduction
This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009]
Entrez Gene ID
11117
UniProt ID
Q9Y6C2
Alternative Names
Elastin Microfibril Interfacer 1; Elastin Microfibril Interface-Located Protein 1; EMI; EMILIN-1; EMILIN; Gp115;
Research Area
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.
Biological Process
Aortic valve morphogenesis Source: BHF-UCL
Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: CAFA
Cell migration Source: CAFA
Elastic fiber assembly Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell activation Source: BHF-UCL
Negative regulation of collagen biosynthetic process Source: BHF-UCL
Negative regulation of collagen fibril organization Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of macrophage migration Source: BHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of extracellular matrix assembly Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Cellular Location
Extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils.
More Infomation

Pivetta, E., Capuano, A., Vescovo, M., Scanziani, E., Cappelleri, A., Vinciguerra, G. L. R., ... & Spessotto, P. (2022). EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction. Matrix Biology, 111, 133-152.

Amor López, A., Mazariegos, M. S., Capuano, A., Ximénez-Embún, P., Hergueta-Redondo, M., Recio, J. Á., ... & Peinado, H. (2021). Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis. International journal of molecular sciences, 22(14), 7406.

Iacomino, M., Doliana, R., Marchese, M., Capuano, A., Striano, P., Spessotto, P., ... & Fiorillo, C. (2020). Distal motor neuropathy associated with novel EMILIN1 mutation. Neurobiology of Disease, 137, 104757.

Fitoussi, R., Beauchef, G., Guéré, C., André, N., & Vié, K. (2019). Localization, fate and interactions of Emilin‐1 in human skin. International Journal of Cosmetic Science, 41(2), 183-193.

Qi, Y., Lv, J., Liu, S., Sun, L., Wang, Y., Li, H., ... & Qiu, W. (2019). TSPAN9 and EMILIN1 synergistically inhibit the migration and invasion of gastric cancer cells by increasing TSPAN9 expression. BMC cancer, 19(1), 1-9.

Capuano, A., Pivetta, E., Sartori, G., Bosisio, G., Favero, A., Cover, E., ... & Spessotto, P. (2019). Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis. Matrix Biology, 83, 97-115.

Louzao-Martinez, L., Van Dijk, C. G., Xu, Y. J., Korn, A., Bekker, N. J., Brouwhuis, R., ... & Cheng, C. (2019). A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion. Matrix biology plus, 4, 100011.

Capuano, A., Pivetta, E., Baldissera, F., Bosisio, G., Wassermann, B., Bucciotti, F., ... & Spessotto, P. (2019). Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis. Matrix Biology, 81, 34-49.

Carnevale, D., Facchinello, N., Iodice, D., Bizzotto, D., Perrotta, M., De Stefani, D., ... & Bressan, G. M. (2018). Loss of EMILIN-1 enhances arteriolar myogenic tone through TGF-β (transforming growth factor-β)–dependent transactivation of EGFR (epidermal growth factor receptor) and is relevant for hypertension in mice and humans. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(10), 2484-2497.

Capuano, A., Fogolari, F., Bucciotti, F., Spessotto, P., Nicolosi, P. A., Mucignat, M. T., ... & Doliana, R. (2018). The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement. Matrix Biology, 66, 50-66.

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For research use only. Not intended for any clinical use.

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