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Mouse Anti-ELOB Recombinant Antibody (CBFYE-0799) (CBMAB-E1247-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0799
Application
WB, IP, ELISA

Basic Information

Immunogen
Recombinant corresponding to full length Elongin B
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Elongin B
Introduction
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Entrez Gene ID
6923
UniProt ID
Q15370
Alternative Names
Elongin B; Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B); RNA Polymerase II Transcription Factor SIII Subunit B; Transcription Elongation Factor B Polypeptide 2; Transcription Elongation Factor B Subunit 2; Elongin 18 KDa Subunit; SIII P18
Biological Process
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Protein-containing complex assembly Source: ProtInc
Protein ubiquitination Source: UniProtKB-UniPathway
Transcription elongation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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