Mouse Anti-EHBP1 Recombinant Antibody (A-8) (CBMAB-E1012-FY)

See all EHBP1 antibodies

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Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

A-8

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

EH Domain Binding Protein 1

Introduction

This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

Human	23301
Mouse	216565
Rat	305556

UniProt ID

Human	Q8NDI1
Mouse	Q69ZW3
Rat	F1LVX2

Alternative Names

EH Domain Binding Protein 1; NACSIN; Testis Tissue Sperm-Binding Protein Li 50e; EH Domain-Binding Protein 1; NPF Calponin-Like Protein; KIAA0903; HPC12

Research Area

May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051).

Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity).

Biological Process

Actin cytoskeleton organization Source: GO_Central
Endocytosis Source: UniProtKB-KW
Protein transport Source: UniProtKB-KW

Cellular Location

Endosome; Cytoplasm; Membrane. Mostly found in cytosol and plasma membrane.

Involvement in disease

Prostate cancer, hereditary, 12 (HPC12):
A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

PTM

Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.

More Infomation

References

Bahrani, E., Kunder, C. A., Teng, J. M., Brown, R. A., Rieger, K. E., Novoa, R. A., & Cloutier, J. M. (2022). Spitz nevus with EHBP1‐ALK fusion and distinctive membranous localization of ALK. Journal of Cutaneous Pathology.

Gao, J., Zhao, L., Luo, Q., Liu, S., Lin, Z., Wang, P., ... & Shi, A. (2020). An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling. PLoS Genetics, 16(5), e1008763.

Rai, A., Bleimling, N., Vetter, I. R., & Goody, R. S. (2020). The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Nature communications, 11(1), 1-16.

Yu, Y., Liu, Q., Li, W., Qu, Y., Zhang, Y., & Liu, T. (2020). Identification of a Novel EHBP1‐MET Fusion in an Intrahepatic Cholangiocarcinoma Responding to Crizotinib. The oncologist, 25(12), 1005-1008.

Liu, C. X., Yin, R. X., Shi, Z. H., Deng, G. X., Zheng, P. F., Wei, B. L., & Guan, Y. Z. (2020). EHBP1 SNPs, Their Haplotypes, and Gene–Environment Interactive Effects on Serum Lipid Levels. ACS omega, 5(13), 7158-7169.

Nakamura, Y., Ochi, Y., Satoh, T., & Satoh, A. K. (2020). Rab10, Crag and Ehbp1 regulate the basolateral transport of Na+ K+ ATPase in Drosophila photoreceptors. Journal of cell science, 133(7), jcs238790.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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