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Mouse Anti-DVL2 Recombinant Antibody (2D11) (CBMAB-D1930-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D11
Antibody Isotype
IgG2b
Application
IHC, IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-320 of human DVL2 (NP_004413) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dishevelled Segment Polarity Protein 2
Introduction
DVL2 belongs to the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Entrez Gene ID
1856
UniProt ID
O14641
Alternative Names
Dishevelled Segment Polarity Protein 2; Dishevelled 2 (Homologous To Drosophila Dsh); Dishevelled, Dsh Homolog 2 (Drosophila); DSH Homolog 2; Dishevelled-2;
Research Area
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Biological Process
Canonical Wnt signaling pathway Source: BHF-UCL
Canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
Cellular protein localization Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in neural plate elongation Source: Ensembl
Heart development Source: BHF-UCLIntracellular signal transduction Source: InterPro
Neural tube closure Source: BHF-UCL
Non-canonical Wnt signaling pathway Source: BHF-UCL
Outflow tract morphogenesis Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of protein tyrosine kinase activity Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription, DNA-templated Source: UniProtKB
Segment specification Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Cellular Location
Nucleus; Cytosol; Cell membrane; Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).
PTM
Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).
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For research use only. Not intended for any clinical use.

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