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Mouse Anti-DUSP5 Recombinant Antibody (D1910) (V2LY-0425-LY1085)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
D1910
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 311-384 mapping at the C-terminus of human DUSP5.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dual specificity phosphatase 5
Entrez Gene ID
1847
UniProt ID
Q16690
Research Area
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
Biological Process
Activation of MAPK activity Source: Reactome
Dephosphorylation Source: UniProtKB
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: GO_Central
MAPK cascade Source: Reactome
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: GO_Central
Cellular Location
Nucleus
More Infomation

Hua, C., Zheng, Q., Zhu, J., Chen, S., Song, Y., van der Veen, S., & Cheng, H. (2022). Human Papillomavirus Type 16 Early Protein E7 Activates Autophagy through Inhibition of Dual-Specificity Phosphatase 5. Oxidative medicine and cellular longevity, 2022.

Kidger, A. M., Saville, M. K., Rushworth, L. K., Davidson, J., Stellzig, J., Ono, M., ... & Keyse, S. M. (2022). Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene, 41(20), 2811-2823.

Tan, L., Bogush, N., Naqvi, E., Calvert, J. W., Graham, R. M., Taylor, W. R., ... & Husain, A. (2021). Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts. Theranostics, 11(10), 4790.

Luo, J., Xue, D., Song, F., Liu, X., Li, W., & Wang, Y. (2020). DUSP5 (dual-specificity protein phosphatase 5) suppresses BCG-induced autophagy via ERK 1/2 signaling pathway. Molecular Immunology, 126, 101-109.

Zhang, H., Zhang, C., Liu, Y., Gao, W., Wang, S., Fang, X., ... & Fan, F. (2020). Influence of dual‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles. Physiological Reports, 8(2), e14345.

Zhang, C., He, X., Murphy, S. R., Zhang, H., Wang, S., Ge, Y., ... & Fan, F. (2019). Knockout of dual-specificity protein phosphatase 5 protects against hypertension-induced renal injury. Journal of Pharmacology and Experimental Therapeutics, 370(2), 206-217.

Wang, L., Hu, J., Qiu, D., Gao, H., Zhao, W., Huang, Y., ... & Chen, Y. (2019). Dual-specificity phosphatase 5 suppresses ovarian cancer progression by inhibiting IL-33 signaling. American Journal of Translational Research, 11(2), 844.

Alleboina, S., Ayalew, D., Peravali, R., Chen, L., Wong, T., & Dokun, A. O. (2019). Dual specificity phosphatase 5 regulates perfusion recovery in experimental peripheral artery disease. Vascular Medicine, 24(5), 395-404.

Gupta, A., Brahmbhatt, J., Syrlybaeva, R., Bodnar, C., Bodnar, N., Bongard, R., ... & Talipov, M. R. (2019). Role of conserved histidine and serine in the HCXXXXXRS motif of human dual-specificity phosphatase 5. Journal of Chemical Information and Modeling, 59(4), 1563-1574.

Zhang, C., He, X., Wang, S., Roman, R. J., Booz, G., & Fan, F. (2018). Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension Induced Chronic Kidney Disease. Hypertension, 72(Suppl_1), A056-A056.

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For research use only. Not intended for any clinical use.

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