Mouse Anti-DSCC1 Recombinant Antibody (B12) (CBMAB-AP1949LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

B12

Antibody Isotype

IgG

Application

ELISA, IHC, WB

Basic Information

Immunogen

Peptide Sequence – KVYNSRRPIS (immunogen peptide is identical

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DNA Replication And Sister Chromatid Cohesion 1

Introduction

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

Entrez Gene ID

79075

UniProt ID

Q9BVC3

Alternative Names

DNA Replication And Sister Chromatid Cohesion 1; Defective In Sister Chromatid Cohesion Protein 1 Homolog; DCC1; Defective In Sister Chromatid Cohesion Homolog 1 (S. Cerevisiae); Defective In Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae); Defective In Sister Chromatid Cohesion 1 Homolog; Sister Chromatid Cohesion Protein DCC1;

Research Area

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Biological Process

DNA duplex unwinding Source: GOC
DNA replication Source: UniProtKB-KW
Maintenance of mitotic sister chromatid cohesion Source: UniProtKB
Positive regulation of DNA-directed DNA polymerase activity Source: UniProtKB
Post-translational protein acetylation Source: UniProtKB
Regulation of DNA replication Source: UniProtKB

Cellular Location

Nucleus

More Infomation

References

Chang, S., Zhu, Y., Xi, Y., Gao, F., Lu, J., Dong, L., ... & Li, H. (2021). High DSCC1 Level Predicts Poor Prognosis of Lung Adenocarcinoma. International Journal of General Medicine, 14, 6961.

Jin, G., Wang, W., Cheng, P., Tian, Y., Zhang, L., & Niu, H. U. (2020). DNA replication and sister chromatid cohesion 1 promotes breast carcinoma progression by modulating the Wnt/β-catenin signaling and p53 protein. Journal of Biosciences, 45(1), 1-11.

Kim, J. T., Cho, H. J., Park, S. Y., Oh, B. M., Hwang, Y. S., Baek, K. E., ... & Lee, H. G. (2019). DNA replication and sister chromatid cohesion 1 (DSCC1) of the replication factor complex CTF18-RFC is critical for colon cancer cell growth. Journal of Cancer, 10(24), 6142.

Xie, X. W., Wang, X. Y., Liao, W. J., Fei, R., Cong, X., Chen, Q., ... & Wang, Y. (2018). Effect of upregulated DNA replication and sister chromatid cohesion 1 expression on proliferation and prognosis in hepatocellular carcinoma. Chinese Medical Journal, 131(23), 2827-2835.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Recombinant Mouse Anti-DSCC1 Recombinant Antibody (P1B2)

Mouse Anti-DSCC1 Recombinant Antibody (V76P1B2/B12)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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