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Mouse Anti-DSCAML1 Monoclonal Antibody (Y20C) (CBMAB-1077-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
Y20C
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human DSCAM-L1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Down syndrome cell adhesion molecule like 1
Introduction
DSCAML1 localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. DSCAML1 is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation.
Entrez Gene ID
57453
UniProt ID
Q8TD84
Alternative Names
DSCAM2
Research Area
Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658).

Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity).

Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
Biological Process
Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Cell fate determination Source: UniProtKB
Central nervous system development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Dorsal/ventral pattern formation Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Cellular Location
Cell membrane; Synapse
Topology
Extracellular: 19-1591
Helical: 1592-1612
Cytoplasmic: 1613-2053
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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