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Mouse Anti-DSCAML1 Monoclonal Antibody (DS1-96) (CBMAB-1078-YC)


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Summary

Host Animal
Mouse
Specificity
Chicken, Mouse
Clone
DS1-96
Antibody Isotype
IgG1, κ
Application
IHC-Fr, WB

Basic Information

Immunogen
Located within the C terminal region of Chicken DSCAML1 (aa 761-1072)
Specificity
Chicken, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Down syndrome cell adhesion molecule like 1
Introduction
DSCAML1 localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. DSCAML1 is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation.
Entrez Gene ID
Chicken428249
Mouse114873
UniProt ID
ChickenE1C8P7
MouseQ4VA61
Alternative Names
Down syndrome cell adhesion molecule like 1; Down syndrome cell adhesion molecule-like protein 1 homolog; Down syndrome cell adhesion molecule-like protein 1
Research Area
Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658).

Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity).

Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
Biological Process
Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Cell fate determination Source: UniProtKB
Central nervous system development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Dorsal/ventral pattern formation Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Cellular Location
Cell membrane; Synapse
Topology
Extracellular: 19-1591
Helical: 1592-1612
Cytoplasmic: 1613-2053
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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