Mouse Anti-DSC1 Recombinant Antibody (D1707) (V2LY-0425-LY947)

Name: Mouse Anti-DSC1 Recombinant Antibody (D1707)
SKU: V2LY-0425-LY947
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

D1707

Antibody Isotype

IgG1, κ

Application

WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen

Amino acids 311-350 mapping within an internal region of human DSC1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

desmocollin 1

Entrez Gene ID

1823

UniProt ID

Q08554

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

Biological Process

Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane; Desmosome

Topology

Extracellular: 135-691
Helical: 692-714
Cytoplasmic: 715-894

More Infomation

References

Zhang, Z., Zhu, H., & Hu, J. (2021). CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell death & disease, 12(2), 1-12.

Faktor, J., Knopfova, L., Lapcik, P., Janacova, L., Paralova, V., Bouchalova, P., ... & Bouchal, P. (2019). Proteomics Identification and Validation of Desmocollin‐1 and Catechol‐O‐Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis. Proteomics, 19(21-22), 1900073.

Choi, H. Y., Ruel, I., Malina, A., Garrod, D. R., Oda, M. N., Pelletier, J., ... & Genest, J. (2018). Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. European Heart Journal, 39(14), 1194-1202.

Rhainds, D., Brodeur, M. R., Rautureau, Y., & Tardif, J. C. (2018). HDL biogenesis revisited: how desmocollin-1 could sabotage reverse cholesterol transport in the arterial wall. European Heart Journal.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-DSC1 Recombinant Antibody (D1706)

Mouse Anti-DSC1 Recombinant Antibody (5F192)

Mouse Anti-DSC1 Recombinant Antibody (A-4)

Rat Anti-DSC1 Recombinant Antibody (15H38)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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