Rat Anti-DSC1 Recombinant Antibody (15H38) (V2LY-0425-LY948)

Name: Rat Anti-DSC1 Recombinant Antibody (15H38)
SKU: V2LY-0425-LY948
Rating: 5 (1 reviews)

See all DSC1 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Rat

Specificity

Human, Mouse

Clone

15H38

Antibody Isotype

IgG2a

Application

FC, WB, IF, IHC

Basic Information

Immunogen

Mouse myeloma cell line derived recombinant mouse Desmocollin-1 (Arg135-Lys691).

Host Species

Rat

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.1 µg/ml
IF(ICC)	8-25 µg/ml
IHC-P	1-25 µg/ml
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

desmocollin 1

Entrez Gene ID

13505

UniProt ID

P55849

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

Biological Process

Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane; Desmosome

Topology

Extracellular: 135-691
Helical: 692-714
Cytoplasmic: 715-894

More Infomation

References

Zhang, Z., Zhu, H., & Hu, J. (2021). CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell death & disease, 12(2), 1-12.

Faktor, J., Knopfova, L., Lapcik, P., Janacova, L., Paralova, V., Bouchalova, P., ... & Bouchal, P. (2019). Proteomics Identification and Validation of Desmocollin‐1 and Catechol‐O‐Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis. Proteomics, 19(21-22), 1900073.

Choi, H. Y., Ruel, I., Malina, A., Garrod, D. R., Oda, M. N., Pelletier, J., ... & Genest, J. (2018). Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. European Heart Journal, 39(14), 1194-1202.

Rhainds, D., Brodeur, M. R., Rautureau, Y., & Tardif, J. C. (2018). HDL biogenesis revisited: how desmocollin-1 could sabotage reverse cholesterol transport in the arterial wall. European Heart Journal.

Totsuka, A., Omori-Miyake, M., Kawashima, M., Yagi, J., & Tsunemi, Y. (2017). Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis. European Journal of Dermatology, 27(3), 247-253.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Rat Anti-DSC1 Recombinant Antibody (15H38)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Rat Anti-DSC1 Recombinant Antibody (15H38)

Related Products

Mouse Anti-DSC1 Recombinant Antibody (A-4)

Rabbit Anti-DSC1 Recombinant Antibody (D1706)

Mouse Anti-DSC1 Recombinant Antibody (D1707)

Mouse Anti-DSC1 Recombinant Antibody (5F192)

Rat Anti-DSC1 Recombinant Antibody (15H38)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: