Mouse Anti-DRD2 Recombinant Antibody (CBYCD-405) (CBMAB-D1679-YC)

Mouse

Human

CBYCD-405

IgG1

IHC

Human DRD2 synthetic peptide, Accession # P14416

Human

IgG1

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Dopamine Receptor D2

DRD2 is the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Dopamine Receptor D2; Dopamine D2 Receptor; Seven Transmembrane Helix Receptor; Dopamine Receptor D2 Isoform; D(2) Dopamine Receptor; D2DR; D2R;

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528).

Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).

Acid secretion Source: Ensembl
Activation of protein kinase activity Source: Ensembl
Adenohypophysis development Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
Adult walking behavior Source: BHF-UCL
Arachidonic acid secretion Source: BHF-UCL
Associative learning Source: BHF-UCL
Auditory behavior Source: Ensembl
Autophagy Source: Ensembl
Axonogenesis Source: BHF-UCL
Behavioral response to cocaine Source: BHF-UCL
Behavioral response to ethanol Source: BHF-UCL
Branching morphogenesis of a nerve Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Cerebral cortex GABAergic interneuron migration Source: BHF-UCL
Circadian regulation of gene expression Source: BHF-UCL
Dopamine metabolic process Source: BHF-UCL
Drinking behavior Source: Ensembl
Excitatory postsynaptic potential Source: ParkinsonsUK-UCL
G protein-coupled receptor internalization Source: Ensembl
Grooming behavior Source: Ensembl
Hyaloid vascular plexus regression Source: UniProtKB
Intracellular signal transduction Source: BHF-UCL
Locomotory behavior Source: BHF-UCL
Long-term memory Source: Ensembl
Negative regulation of adenylate cyclase activity Source: BHF-UCL
Negative regulation of blood pressure Source: BHF-UCL
Negative regulation of cell death Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: GO_Central
Negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
Negative regulation of dopamine secretion Source: Ensembl
Negative regulation of innate immune response Source: Ensembl
Negative regulation of insulin secretion Source: Ensembl
Negative regulation of protein kinase B signaling Source: BHF-UCL
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of protein secretion Source: BHF-UCL
Negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
Negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
Nervous system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
Neuron-neuron synaptic transmission Source: BHF-UCL
Orbitofrontal cortex development Source: Ensembl
Peristalsis Source: BHF-UCL
Phospholipase C-activating dopamine receptor signaling pathway Source: MGI
Pigmentation Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: BHF-UCL
Positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of glial cell-derived neurotrophic factor production Source: CACAO
Positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
Positive regulation of growth hormone secretion Source: BHF-UCL
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of neuroblast proliferation Source: BHF-UCL
Positive regulation of receptor internalization Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of urine volume Source: Ensembl
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Prepulse inhibition Source: BHF-UCL
Protein localization Source: BHF-UCL
Regulation of dopamine secretion Source: GO_Central
Regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Regulation of heart rate Source: BHF-UCL
Regulation of locomotion involved in locomotory behavior Source: Ensembl
Regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
Regulation of phosphoprotein phosphatase activity Source: Ensembl
Regulation of potassium ion transport Source: BHF-UCL
Regulation of sodium ion transport Source: BHF-UCL
Regulation of synapse structural plasticity Source: Ensembl
Regulation of synaptic transmission, GABAergic Source: BHF-UCL
Regulation of synaptic vesicle exocytosis Source: Ensembl
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to amphetamine Source: BHF-UCL
Response to axon injury Source: Ensembl
Response to cocaine Source: BHF-UCL
Response to drug Source: BHF-UCL
Response to histamine Source: BHF-UCL
Response to hypoxia Source: Ensembl
Response to inactivity Source: Ensembl
Response to iron ion Source: Ensembl
Response to light stimulus Source: BHF-UCL
Response to morphine Source: BHF-UCL
Response to nicotine Source: Ensembl
Response to toxic substance Source: Ensembl
Sensory perception of smell Source: BHF-UCL
Striatum development Source: Ensembl
Synapse assembly Source: BHF-UCL
Temperature homeostasis Source: BHF-UCL
Visual learning Source: BHF-UCL
Wnt signaling pathway Source: Ensembl

Golgi apparatus membrane; Cell membrane

Extracellular: 1-37
Helical: 38-60
Cytoplasmic: 61-70
Helical: 71-93
Extracellular: 94-108
Helical: 109-130
Cytoplasmic: 131-151
Helical: 152-172
Extracellular: 173-188
Helical: 189-213
Cytoplasmic: 214-373
Helical: 374-395
Extracellular: 396-409
Helical: 410-431
Cytoplasmic: 432-443

Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.