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Rabbit Anti-DRD1 Monoclonal Antibody (Y15C) (CBMAB-1064-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
Y15C
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthesized peptide derived from human DRD1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dopamine Receptor D1
Introduction
DRD1 is the D1 subtype of the dopamine receptor, which is the most abundant dopamine receptor in the central nervous system. DRD1 coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases and regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events.
Entrez Gene ID
Human1812
Mouse13488
Rat24316
UniProt ID
HumanP21728
MouseQ61616
RatP18901
Alternative Names
DADR; DRD1A
Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Biological Process
Activation of adenylate cyclase activity Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adult walking behavior Source: BHF-UCL
Cellular response to catecholamine stimulus Source: BHF-UCL
Cellular response to dopamine Source: CAFA
Cerebral cortex GABAergic interneuron migration Source: BHF-UCL
Dopamine metabolic process Source: BHF-UCL
Dopamine receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: BHF-UCL
Mating behavior Source: BHF-UCL
Phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: BHF-UCL
Positive regulation of gene expression Source: CAFA
Positive regulation of potassium ion transport Source: BHF-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
Prepulse inhibition Source: BHF-UCL
Regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Response to drug Source: BHF-UCL
Synapse assembly Source: BHF-UCL
Transmission of nerve impulse Source: BHF-UCL
Vasodilation Source: InterPro
Visual learning Source: BHF-UCL
Cellular Location
Endoplasmic reticulum membrane; Cell membrane; Dendrite; Dendritic spine. Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Topology
Extracellular: 1-23
Helical: 24-49
Cytoplasmic: 50-60
Helical: 61-87
Extracellular: 88-96
Helical: 97-119
Cytoplasmic: 120-138
Helical: 139-163
Extracellular: 164-192
Helical: 193-218
Cytoplasmic: 219-272
Helical: 273-299
Extracellular: 300-312
Helical: 313-337
Cytoplasmic: 338-446
More Infomation

Zhuang, Y., Krumm, B., Zhang, H., Zhou, X. E., Wang, Y., Huang, X. P., ... & Xu, H. E. (2021). Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell research, 31(5), 593-596.

Wang, Z., Wen, P., Hu, B., Cao, S., Shi, X., Guo, W., & Zhang, S. (2021). Dopamine and dopamine receptor D1 as a novel favourable biomarker for hepatocellular carcinoma. Cancer Cell International, 21(1), 1-12.

Sibley, D. R., Luderman, K. D., Free, R. B., & Shi, L. (2021). Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal Transduction and Targeted Therapy, 6(1), 1-2.

Sun, Y., Wang, X., Tian, S., Chen, Z., Wang, H., Xue, L., ... & Lu, Q. (2021). An Investigation into the Association Between Dopamine Receptor D1 Multilocus Genetic Variation, Multiparametric Magnetic Resonance Imaging, and Antidepressant Treatment. Journal of Magnetic Resonance Imaging.

Yan, Y., Pan, J., Chen, Y., Xing, W., Li, Q., Wang, D., ... & Chen, D. (2020). Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma. Cancer Communications, 40(12), 694-710.

Yang, K., Wei, M., Yang, Z., Fu, Z., Xu, R., Cheng, C., ... & Le, W. (2020). Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity. Cellular Oncology, 43(6), 1175-1190.

Tian, J., Guo, L., Sui, S., Driskill, C., Phensy, A., Wang, Q., ... & Du, H. (2019). Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′ s disease. Science translational medicine, 11(505), eaav6278.

Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., ... & Tschumperlin, D. J. (2019). Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Science translational medicine, 11(516), eaau6296.

Minami, K., Liu, S., Liu, Y., Chen, A., Wan, Q., Na, S., ... & Yokota, H. (2017). Inhibitory effects of dopamine receptor D1 agonist on mammary tumor and bone metastasis. Scientific reports, 7(1), 1-12.

Park, S. J., Yang, H., Lee, S. H., Song, H. S., Park, C. S., Bae, J., ... & Jang, J. (2017). Dopamine receptor D1 agonism and antagonism using a field-effect transistor assay. Acs Nano, 11(6), 5950-5959.

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For research use only. Not intended for any clinical use.

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