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Mouse Anti-DPYSL2 Recombinant Antibody (3F4) (CBMAB-D1649-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F4
Antibody Isotype
IgG3
Application
IHC, WB

Basic Information

Immunogen
Human brain homogenate
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dihydropyrimidinase Like 2
Introduction
DPYSL2 belongs to the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease.
Entrez Gene ID
1808
UniProt ID
Q16555
Alternative Names
Dihydropyrimidinase Like 2; Unc-33-Like Phosphoprotein 2; CRMP-2; ULIP-2; CRMP2; DRP-2; ULIP2; N2A3;
Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Biological Process
Axon guidance Source: InterPro
Brain development Source: InterPro
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: UniProtKB
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Regulation of axon extension Source: InterPro
Regulation of neuron differentiation Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cytoskeleton; Cytosol; Membrane. Tightly but non-covalently associated with membranes.
PTM
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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