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Mouse Anti-DNM1 Monoclonal Antibody (Hudy 1) (CBMAB-1088-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
Hudy 1
Antibody Isotype
IgG
Application
ICC, IP, WB

Basic Information

Immunogen
Recombinant full length human protein
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in the proline-rich domain of Dynamin 1(aa 822-838): SPDPFGPPPQVPSRPNR.

Target

Full Name
Dynamin 1
Introduction
Dynamin 1 possesses unique mechanochemical properties used to tubulate and sever membranes, which is a member of the dynamin subfamily of GTP-binding proteins. Dynamin 1 is involved in clathrin-mediated endocytosis and other vesicular trafficking processes.
Entrez Gene ID
Human1759
Mouse13429
Rat140694
Cattle508794
UniProt ID
HumanQ05193
MouseP39053
RatP21575
CattleQ08DF4
Alternative Names
DNM; EIEE31
Function
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Biological Process
Dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
Endocytosis Source: BHF-UCL
Endosome organization Source: BHF-UCL
G protein-coupled receptor internalization Source: Ensembl
Membrane fusion Source: GO_Central
Mitochondrial fission Source: GO_Central
Modulation of chemical synaptic transmission Source: Ensembl
Positive regulation of synaptic vesicle endocytosis Source: Ensembl
Postsynaptic neurotransmitter receptor internalization Source: GO_Central
Receptor internalization Source: GO_Central
Receptor-mediated endocytosis Source: UniProtKB
Regulation of synapse structure or activity Source: GO_Central
Response to amyloid-beta Source: Ensembl
Synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
Toxin transport Source: Ensembl
Cellular Location
Cytoskeleton; Cytoplasm. Microtubule-associated.
Involvement in disease
Developmental and epileptic encephalopathy 31 (DEE31):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
More Infomation

Shi, B., Jin, Y. H., & Wu, L. G. (2022). Dynamin 1 controls vesicle size and endocytosis at hippocampal synapses. Cell Calcium, 103, 102564.

Sahly, A. N., Krochmalnek, E., St-Onge, J., Srour, M., & Myers, K. A. (2020). Severe DNM1 encephalopathy with dysmyelination due to recurrent splice site pathogenic variant. Human Genetics, 139(12), 1575-1578.

Xie, X., Wang, Y., Yu, D., Xie, R., Liu, Z., & Huang, B. (2020). DNM1, a dynamin-related protein that contributes to endocytosis and peroxisome fission, is required for the vegetative growth, sporulation, and virulence of Metarhizium robertsii. Applied and environmental microbiology, 86(17), e01217-20.

Li, H., Fang, F., Xu, M., Liu, Z., Zhou, J., Wang, X., ... & Han, T. (2019). Clinical assessments and EEG analyses of encephalopathies associated with dynamin-1 mutation. Frontiers in Pharmacology, 1454.

Xie, A. J., Hou, T. Y., Xiong, W., Huang, H. Z., Zheng, J., Li, K., ... & Zhu, L. Q. (2019). Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathway. Aging Cell, 18(3), e12929.

Brereton, E., Fassi, E., Araujo, G. C., Dodd, J., Telegrafi, A., Pathak, S. J., & Shinawi, M. (2018). Mutations in the PH Domain of DNM 1 are associated with a nonepileptic phenotype characterized by developmental delay and neurobehavioral abnormalities. Molecular genetics & genomic medicine, 6(2), 294-300.

Bohuszewicz, O., & Low, H. H. (2018). Structure of a mitochondrial fission dynamin in the closed conformation. Nature structural & molecular biology, 25(8), 722-731.

Kolnikova, M., Skopkova, M., Ilencikova, D., Foltan, T., Payerova, J., Danis, D., ... & Gasperikova, D. (2018). DNM1 encephalopathy− atypical phenotype with hypomyelination due to a novel de novo variant in the DNM1 gene. Seizure-European Journal of Epilepsy, 56, 31-33.

Von Spiczak, S., Helbig, K. L., Shinde, D. N., Huether, R., Pendziwiat, M., Lourenço, C., ... & EuroEPINOMICS-RES NLES Working Group. (2017). DNM1 encephalopathy: a new disease of vesicle fission. Neurology, 89(4), 385-394.

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For research use only. Not intended for any clinical use.

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