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Rabbit Anti-DHCR24 Recombinant Antibody (CBXS-1259) (CBMAB-S4118-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1259
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.887 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
24-Dehydrocholesterol Reductase
Introduction
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Entrez Gene ID
1718
UniProt ID
Q15392
Alternative Names
24-Dehydrocholesterol Reductase; Desmosterol-To-Cholesterol Enzyme; Diminuto/Dwarf1 Homolog; Seladin-1; 3 Beta-Hydroxysterol Delta 24-Reductase; 3-Beta-Hydroxysterol Delta-24-Reductase; Delta(24)-Sterol Reductase; Selective AD Indicator 1;
Function
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193).

In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141).

Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892).
Biological Process
Apoptotic process Source: UniProtKB
Cell cycle arrest Source: UniProtKB
Cholesterol biosynthetic process Source: MGI
Cholesterol biosynthetic process via desmosterol Source: UniProtKB
Cholesterol biosynthetic process via lathosterol Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Regulation of neuron death Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Skin development Source: UniProtKB
Steroid metabolic process Source: GO_Central
Tissue development Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane
Involvement in disease
Desmosterolosis (DESMOS):
Rare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells.
Topology
Lumenal: 23-31
Helical: 32-52
Cytoplasmic: 53-516
More Infomation

Yao, M., Li, F., Xu, L., Ma, L., & Zhang, S. (2022). 24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation. Bioengineered, 13(1), 155-163.

Kohlhaas, J., Jäger, M. A., Lust, L., De La Torre, C., Hecker, M., & Korff, T. (2021). Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Experimental Cell Research, 399(2), 112446.

Mack, Y. S. I., Dehari, M., Morooka, N., & Nagata, S. (2021). Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, Gryllus bimaculatus. Insects, 12(9), 782.

Yavuz, U., Alaylıoğlu, M., Şengül, B., Karras, S. N., Gezen-Ak, D., & Dursun, E. (2021). Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons. In Vitro Cellular & Developmental Biology-Animal, 57(7), 704-714.

Wang, N., Gong, Z., Wang, J., Xu, W., Yang, Q., & Chen, S. (2021). Characterization of Chinese tongue sole (Cynoglossus semilaevis) 24-dehydrocholesterol reductase: Expression profile, epigenetic modification, and its knock-down effect. General and comparative endocrinology, 312, 113870.

Qiu, T., Cao, J., Chen, W., Wang, J., Wang, Y., Zhao, L., ... & Gu, H. (2020). 24‐Dehydrocholesterol reductase promotes the growth of breast cancer stem‐like cells through the Hedgehog pathway. Cancer science, 111(10), 3653-3664.

Tallorin, L., Villareal, V. A., Hsia, C. Y., Rodgers, M. A., Burri, D. J., Pfeil, M. P., ... & Yang, P. L. (2020). Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase. Journal of Biological Chemistry, 295(35), 12426-12436.

Simonen, P., Li, S., Chua, N. K., Lampi, A. M., Piironen, V., Lommi, J., ... & Gylling, H. (2020). Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase. Journal of Internal Medicine, 288(5), 560-569.

Müller, C., Hemmers, S., Bartl, N., Plodek, A., Körner, A., Mirakaj, V., ... & Bracher, F. (2017). New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. European Journal of Medicinal Chemistry, 140, 305-320.

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For research use only. Not intended for any clinical use.

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