Mouse Anti-DAP3 Recombinant Antibody (2D4) (CBMAB-D0210-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2D4

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 161-398

Target

Full Name

death associated protein 3

Introduction

DAP3 is a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. DAP3 potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.

Entrez Gene ID

7818

UniProt ID

P51398

Alternative Names

Death Associated Protein 3; Mitochondrial Small Ribosomal Subunit Protein MS29; Ionizing Radiation Resistance Conferring Protein; Mitochondrial 28S Ribosomal Protein S29; MRP-S29; MRPS29;

Function

Involved in mediating interferon-gamma-induced cell death.

Biological Process

Apoptotic signaling pathway Source: ProtInc
Mitochondrial translational elongation Source: Reactome
Mitochondrial translational termination Source: Reactome

Cellular Location

Mitochondrion

More Infomation

References

Sui, L., Ye, L., Sanders, A. J., Yang, Y., Hao, C., Hargest, R., & Jiang, W. G. (2021). Expression of death associated proteins DAP1 and DAP3 in human pancreatic cancer. Anticancer Research, 41(5), 2357-2362.

Sato, Y., Yoshino, H., Kashiwakura, I., & Tsuruga, E. (2021). DAP3 is involved in modulation of cellular radiation response by RIG-I-like receptor agonist in human lung adenocarcinoma cells. International Journal of Molecular Sciences, 22(1), 420.

Sui, L., Zeng, J., Ye, L., Sanders, A. J., Zhao, H., Jiang, A., ... & Jiang, W. G. (2021). PTH-100 DAP3 and the DAP3 Binding Cell Death Enhancer-1 (DELE1) in human colorectal cancer.

Han, J., An, O., Hong, H., Chan, T. H. M., Song, Y., Shen, H., ... & Chen, L. (2020). Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression. Science advances, 6(25), eaba5136.

Jia, Y., Li, Z., Cheng, X., Wu, X., Pang, F., Shi, J., ... & Ji, J. (2019). Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis. Journal of Investigative Medicine, 67(5), 856-861.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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