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Mouse Anti-DACH1 Recombinant Antibody (740) (CBMAB-AP1821LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
740
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of DACH1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dachshund Family Transcription Factor 1
Introduction
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Entrez Gene ID
Human1602
Mouse13134
Rat306096
UniProt ID
HumanQ9UI36
MouseQ9QYB2
RatF1M0Y6
Alternative Names
Dachshund Family Transcription Factor 1; DACH; Dachshund Homolog 1 (Drosophila); Dachshund Homolog (Drosophila); Dachshund Homolog 1; Dac Homolog; Dach1;
Function
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity).

Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Biological Process
Cell population proliferation Source: Ensembl
Development of primary female sexual characteristics Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of cell proliferation involved in contact inhibition Source: Ensembl
Negative regulation of DNA biosynthetic process Source: CACAO
Negative regulation of fibroblast proliferation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: CACAO
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of nuclear cell cycle DNA replication Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory gaseous exchange by respiratory system Source: Ensembl
Suckling behavior Source: Ensembl
Cellular Location
Nucleus
More Infomation

Zhou, X., Lu, Y., Guo, P., & Zhou, C. (2021). Upregulation of microRNA‑140‑3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle‑dependent mechanisms. Molecular medicine reports, 23(2), 1-1.

MacGrogan, D., & de la Pompa, J. L. (2021). DACH1-Driven Arterialization: Angiogenic Therapy for Ischemic Heart Disease?. Circulation Research, 129(7), 717-719.

Zhang, Y. L., Wang, J. M., Yin, H., Wang, S. B., He, C. L., & Liu, J. (2020). DACH1, a novel target of miR-218, participates in the regulation of cell viability, apoptosis, inflammatory response, and epithelial-mesenchymal transition process in renal tubule cells treated by high-glucose. Renal Failure, 42(1), 463-473.

Wang, R., Shen, J., Su, N., Wang, Q., Zhang, M., & Liu, C. (2020). MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1. Human cell, 33(4), 1091-1098.

Kim, Y. K., Lee, H., Ismail, T., Kim, Y., & Lee, H. S. (2020). Dach1 regulates neural crest migration during embryonic development. Biochemical and Biophysical Research Communications, 527(4), 896-901.

Cao, W., & Sun, J. (2019). MicroRNA-200c promotes tumor cell proliferation and migration by directly targeting dachshund family transcription factor 1 by the Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma. Anti-Cancer Drugs, 30(3), 218-224.

Zhou, Q., Li, W., Kong, D., Liu, Z., Shi, Z., Ma, X., ... & Jiang, J. (2019). DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma. Cancer medicine, 8(9), 4380-4388.

Cao, J., Yan, X. R., Liu, T., Han, X. B., Yu, J. J., Liu, S. H., & Wang, L. B. (2017). MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer. Oncology letters, 14(3), 3795-3802.

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For research use only. Not intended for any clinical use.

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