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Rabbit Anti-CXCL9 Recombinant Antibody (050) (CBMAB-C1785-LY)


See all CXCL9 antibodies
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Summary

Host Animal
Rabbit
Specificity
Human
Clone
050
Antibody Isotype
IgG
Application
ELISA, ELISA(Det)

Basic Information

Immunogen
Recombinant Human CXCL9 / MIG protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 9
Introduction
CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Endotheliitis and Sydenham Chorea. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL10.
Entrez Gene ID
4283
UniProt ID
Q07325
Alternative Names
C-X-C Motif Chemokine Ligand 9; Monokine Induced By Gamma Interferon; Monokine Induced By Interferon-Gamma; Gamma-Interferon-Induced Monokine; Chemokine (C-X-C Motif) Ligand 9; Small-Inducible Cytokine B9; Humig;
Function
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular defense response Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: UniProtKB
Defense response Source: ProtInc
Defense response to virus Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of myoblast differentiation Source: Ensembl
Positive regulation of myoblast fusion Source: Ensembl
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Secreted
More Infomation

Mirzarakhmetova, D. T., & Baltaeva, Y. Y. (2021). Molecular Genetic Analysis Of CXC Motif Chemokine Ligand 9 (CXCL9) As A Novel Biomarker In Atherosclerosis. The American Journal of Applied sciences, 3(05), 24-30.

Magnusen, A. F., Rani, R., McKay, M. A., Hatton, S. L., Nyamajenjere, T. C., Magnusen, D. N. A., ... & Pandey, M. K. (2021). CXC Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease. International Journal of Molecular Sciences, 22(23), 12712.

Aguilera-Durán, G., & Romo-Mancillas, A. (2020). Computational study of CXC chemokine receptor (CXCR) 3 binding with its natural agonists chemokine (CXC Motif) ligand (CXCL) 9, 10 and 11 and with synthetic antagonists: Insights of receptor activation towards drug design for vitiligo. Molecules, 25(19), 4413.

Wu, D., Kittana, H., Shu, J., Kachman, S. D., Cui, J., Ramer-Tait, A. E., & Zempleni, J. (2019). Dietary depletion of milk exosomes and their microRNA cargos elicits a depletion of miR-200a-3p and elevated intestinal inflammation and chemokine (CXC motif) ligand 9 expression in Mdr1a−/− mice. Current developments in nutrition, 3(12), nzz122.

Tan, S., Wang, K., Sun, F., Li, Y., & Gao, Y. (2018). CXCL9 promotes prostate cancer progression through inhibition of cytokines from T cells. Molecular medicine reports, 18(2), 1305-1310.

Elia, G., & Guglielmi, G. (2018). CXCL9 chemokine in ulcerative colitis. La Clinica Terapeutica, 169(5), e235-e241.

Ke, Y., Dang, E., Shen, S., Zhang, T., Qiao, H., Chang, Y., ... & Wang, G. (2017). Semaphorin4D drives CD8+ T-Cell lesional trafficking in oral lichen planus via CXCL9/CXCL10 upregulations in oral keratinocytes. Journal of Investigative Dermatology, 137(11), 2396-2406.

Amin, M., Vakilian, A., Mahmoodi, M. H., Hassanshahi, G., Falahati-Pour, S. K., Dolatabadi, M. R., & Nadimi, A. E. (2017). Circulatory levels of CXC motif chemokine ligands 1, 9, and 10 are elevated in patients with ischemic stroke. The Eurasian journal of medicine, 49(2), 92.

Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., ... & Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13(6), 4224-4230.

Han, J., Gu, M. J., Yoo, I., Choi, Y., Jang, H., Kim, M., ... & Ka, H. (2017). Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs. Biology of reproduction, 97(1), 69-80.

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For research use only. Not intended for any clinical use.

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