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Mouse Anti-CXCL11 Recombinant Antibody (CBFYC-2497) (CBMAB-C2571-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2497
Antibody Isotype
IgG2
Application
Neut, WB

Basic Information

Immunogen
Recombinant protein corresponding to human CXCL11
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-X-C motif) ligand 11
Introduction
CXCL11 (C-X-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CXCL11 include Nasal Cavity Cancer and Nasal Cavity Adenocarcinoma. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR3 chemokine receptor binding.
Entrez Gene ID
6373
UniProt ID
O14625
Alternative Names
C-X-C Motif Chemokine Ligand 11; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11; Interferon-Inducible T-Cell Alpha Chemoattractant; Interferon Gamma-Inducible Protein 9; Chemokine (C-X-C Motif) Ligand 11; Beta-R1; SCYB11; SCYB9B; I-TAC; H174
Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB
Cellular Location
Secreted
More Infomation

Cao, Y., Jiao, N., Sun, T., Ma, Y., Zhang, X., Chen, H., ... & Zhang, Y. (2021). CXCL11 correlates with antitumor immunity and an improved prognosis in colon cancer. Frontiers in cell and developmental biology, 9.

Kumaravel, S., Singh, S., Roy, S., Venkatasamy, L., White, T. K., Sinha, S., ... & Chakraborty, S. (2020). CXCL11-CXCR3 axis mediates tumor lymphatic cross talk and inflammation-induced tumor, promoting pathways in head and neck cancers. The American journal of pathology, 190(4), 900-915.

Kameda, M., Otsuka, M., Chiba, H., Kuronuma, K., Hasegawa, T., Takahashi, H., & Takahashi, H. (2020). CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases–associated interstitial lung disease and interstitial pneumonia with autoimmune features. PloS one, 15(11), e0241719.

Zhang, Y., Zhao, W., Li, S., Lv, M., Yang, X., Li, M., & Zhang, Z. (2019). CXCL11 promotes self-renewal and tumorigenicity of α2δ1+ liver tumor-initiating cells through CXCR3/ERK1/2 signaling. Cancer letters, 449, 163-171.

Han, B., Feng, D., Yu, X., Liu, Y., Yang, M., Luo, F., ... & Liu, F. (2018). MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11. Experimental and therapeutic medicine, 16(3), 1935-1943.

Tokunaga, R., Zhang, W. U., Naseem, M., Puccini, A., Berger, M. D., Soni, S., ... & Lenz, H. J. (2018). CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation–a target for novel cancer therapy. Cancer treatment reviews, 63, 40-47.

Han, J., Gu, M. J., Yoo, I., Choi, Y., Jang, H., Kim, M., ... & Ka, H. (2017). Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs. Biology of reproduction, 97(1), 69-80.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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