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Mouse Anti-CUL9 Recombinant Antibody (CBCNC-099) (CBMAB-C0994-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-099
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide

Target

Full Name
Cullin 9
Introduction
CUL9 (Cullin 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is CUL7.
Entrez Gene ID
23113
UniProt ID
Q8IWT3
Alternative Names
Cullin 9; P53-Associated Parkin-Like Cytoplasmic Protein; Parkin-Like Cytoplasmic P53 Binding Protein; UbcH7-Associated Protein 1; CUL-9; H7AP1; PARC; Cullin-9; KIAA0708;
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696).

Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Biological Process
Microtubule cytoskeleton organization Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Regulation of mitotic nuclear division Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: InterPro
Cellular Location
Cytoplasm
PTM
In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
Neddylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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