Mouse Anti-CTTN Recombinant Antibody (C6437) (CBMAB-C6437-LY)

Name: Mouse Anti-CTTN Recombinant Antibody (C6437)
SKU: CBMAB-C6437-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Pig

Clone

C6437

Antibody Isotype

IgG1, κ

Application

ELISA, IF

Basic Information

Immunogen

Recombinant protein corresponding to AA 1 to 513 from human Cortactin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Target

Full Name

Cortactin

Entrez Gene ID

Human	2017
Mouse	13043
Rat	60465

UniProt ID

Human	Q14247
Mouse	Q60598
Rat	Q66HL2

Function

Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879).

Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity).

Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity).

Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290).

Plays a role in focal adhesion assembly and turnover (By similarity).

In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316).

Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782).

Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity).

Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Actin filament polymerization Source: InterPro
Cell motility Source: UniProtKB
Dendritic spine maintenance Source: Ensembl
Focal adhesion assembly Source: UniProtKB
Intracellular protein transport Source: UniProtKB
Lamellipodium organization Source: UniProtKB
Membrane organization Source: Reactome
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Neuron projection morphogenesis Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of smooth muscle contraction Source: UniProtKB
Receptor-mediated endocytosis Source: UniProtKB
Regulation of actin filament polymerization Source: GO_Central
Regulation of autophagy of mitochondrion Source: Ensembl
Regulation of axon extension Source: UniProtKB
Substrate-dependent cell migration, cell extension Source: Ensembl

Cellular Location

Cell membrane; Cytoskeleton; Lamellipodium; Ruffle; Dendrite; Cell projection; Podosome; Cell junction; Focal adhesion; Clathrin-coated pit; Dendritic spine; Cell cortex. Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).

PTM

Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.

More Infomation

References

Belvitch, P., Casanova, N., Sun, X., Camp, S. M., Sammani, S., Brown, M. E., ... & Dudek, S. M. (2022). A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Translational Research.

Zhao, Y., Lei, Y., He, S. W., Li, Y. Q., Wang, Y. Q., Hong, X. H., ... & Tang, L. L. (2020). Hypermethylation of UCHL1 promotes metastasis of nasopharyngeal carcinoma by suppressing degradation of cortactin (CTTN). Cells, 9(3), 559.

Ramos‐García, P., González‐Moles, M. Á., Ayen, A., González‐Ruiz, L., Ruiz‐Ávila, I., & Gil‐Montoya, J. A. (2019). Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: systematic review and meta‐analysis. Head & Neck, 41(6), 1963-1978.

Ramos‐García, P., González‐Moles, M. Á., González‐Ruiz, L., Ayén, Á., Ruiz‐Ávila, I., Navarro‐Triviño, F. J., & Gil‐Montoya, J. A. (2019). An update of knowledge on cortactin as a metastatic driver and potential therapeutic target in oral squamous cell carcinoma. Oral Diseases, 25(4), 949-971.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CTTN Matched Antibody Pair (319)

Related Products

CTTN Matched Antibody Pair (319)

Mouse Anti-CTTN Recombinant Antibody (CBCNC-497)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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