Mouse Anti-CTSF Recombinant Antibody (CBXC-2812) (V2LY-0125-LY433)

Name: Mouse Anti-CTSF Recombinant Antibody (CBXC-2812)
SKU: V2LY-0125-LY433
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-2812

Antibody Isotype

IgG1

Application

WB, IP, IHC

Basic Information

Immunogen

Recombinant human Cathepsin F Ala20-Asp484.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/mL
IP	25 μg/mL
IHC	8-25 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cathepsin E

Entrez Gene ID

8722

UniProt ID

Q9UBX1

Function

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: GO_Central

Cellular Location

Lysosome

Involvement in disease

Ceroid lipofuscinosis, neuronal, 13 (CLN13):
A form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.

More Infomation

References

Wei, S., Liu, W., Xu, M., Qin, H., Liu, C., Zhang, R., ... & Wang, Q. (2022). Cathepsin F and Fibulin-1 as novel diagnostic biomarkers for brain metastasis of non-small cell lung cancer. British Journal of Cancer, 1-11.

Song, L., Wang, X., Cheng, W., Wu, Y., Liu, M., Liu, R., ... & Ji, F. (2021). Expression signature, prognosis value and immune characteristics of cathepsin F in non-small cell lung cancer identified by bioinformatics assessment. BMC pulmonary medicine, 21(1), 1-17.

Yao, C., Zhou, Y., Wang, H., Deng, F., Chen, Y., Zhu, X., ... & Sheng, X. (2021). Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression. Stem Cell Research & Therapy, 12(1), 1-16.

Zheng, L., Cao, J., Liu, L., Xu, H., Chen, L., Kang, L., & Gao, L. (2021). Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(5), G816-G828.

Ji, C., Zhao, Y., Kou, Y. W., Shao, H., Guo, L., Bao, C. H., ... & Wang, Q. (2018). Cathepsin F knockdown induces proliferation and inhibits apoptosis in gastric cancer cells. Oncology research, 26(1), 83.

Gao, C., Fu, Q., Su, B., Song, H., Zhou, S., Tan, F., & Li, C. (2017). The involvement of cathepsin F gene (CTSF) in turbot (Scophthalmus maximus L.) mucosal immunity. Fish & Shellfish Immunology, 66, 270-279.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CTSF Recombinant Antibody (CBYY-C2317)

Rat Anti-CTSF Recombinant Antibody (CBXC-0997)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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