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Rabbit Anti-CTSE Recombinant Antibody (215) (CBMAB-C4387-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
215
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse Cathepsin E / CTSE protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cathepsin E
Introduction
CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Adenocarcinoma and Rosai-Dorfman Disease. Among its related pathways are Innate Immune System and MHC class II antigen presentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity.
An important paralog of this gene is PGA3.
Entrez Gene ID
13034
UniProt ID
P70269
Function
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Protein autoprocessing Source: Ensembl
Proteolysis Source: ARUK-UCL
Cellular Location
Endosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
PTM
Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
More Infomation

Zhu, Z., Wang, Q., Chen, X., Wang, Q., Yan, C., Zhao, X., ... & Zhu, W. H. (2022). An Enzyme‐Activatable Aggregation‐Induced‐Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E. Advanced Materials, 34(3), 2107444.

Wu, Y., Zhou, W., Yang, Z., Li, J., & Jin, Y. (2022). miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E. International Journal of Toxicology, 10915818211069270.

Kim, J. W., Cho, J. Y., Kim, J., Kim, D. G., Nam, B. H., Kim, Y. O., ... & Kong, H. J. (2020). First report of cathepsin E in a teleost (Korean rose bitterling, Rhodeus uyekii): Molecular characterisation and tissue distribution. Developmental & Comparative Immunology, 106, 103607.

Pontious, C., Kaul, S., Hong, M., Hart, P. A., Krishna, S. G., Lara, L. F., ... & Cruz-Monserrate, Z. (2019). Cathepsin E expression and activity: Role in the detection and treatment of pancreatic cancer. Pancreatology, 19(7), 951-956.

Hiramatsu, S., Watanabe, K. S., Zeggar, S., Asano, Y., Miyawaki, Y., Yamamura, Y., ... & Wada, J. (2019). Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells. Scientific reports, 9(1), 1-13.

Mengwasser, J., Babes, L., Cordes, S., Mertlitz, S., Riesner, K., Shi, Y., ... & Penack, O. (2017). Cathepsin E deficiency ameliorates graft-versus-host disease and modifies dendritic cell motility. Frontiers in immunology, 8, 203.

Gonçalves, N. P., Moreira, J., Martins, D., Vieira, P., Obici, L., Merlini, G., ... & Saraiva, M. J. (2017). Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system. Journal of Neuroinflammation, 14(1), 1-12.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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