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Rat Anti-CTSA Recombinant Antibody (4A12) (CBMAB-C6560-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
4A12
Antibody Isotype
IgG2
Application
IHC, WB

Basic Information

Immunogen
Mouse recombinant protein of Cathepsin A.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:1,000
IHC1:100-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
0.5 mg/ml

Target

Full Name
Cathepsin A
Entrez Gene ID
19025
UniProt ID
P16675
Function
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Biological Process
Glycosphingolipid metabolic process Source: Reactome
Intracellular protein transport Source: ProtInc
Negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Proteolysis Source: ParkinsonsUK-UCL
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Cellular Location
Lysosome
Involvement in disease
Galactosialidosis (GSL):
A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
More Infomation

Wang, H., Xu, F., Yang, F., Lv, L., & Jiang, Y. (2021). Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. Scientific Reports, 11(1), 1-15.

Park, S., Kwon, W., Park, J. K., Baek, S. M., Lee, S. W., Cho, G. J., ... & Choi, S. K. (2020). Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer. Archives of Biochemistry and Biophysics, 688, 108407.

Hu, B., Zhu, X., & Lu, J. (2020). Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells. Molecular Medicine Reports, 21(6), 2553-2559.

Kim, J. W., Mahiddine, F. Y., & Kim, G. A. (2020). Leptin modulates the metastasis of canine inflammatory mammary adenocarcinoma cells through downregulation of lysosomal protective protein cathepsin a (Ctsa). International journal of molecular sciences, 21(23), 8963.

Toss, M. S., Miligy, I. M., Haj‐Ahmad, R., Gorringe, K. L., AlKawaz, A., Mittal, K., ... & Rakha, E. A. (2019). The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ. Histopathology, 74(7), 1025-1035.

Nakajima, H., Ueno, M., Adachi, K., Nanba, E., Narita, A., Tsukimoto, J., ... & Kawakami, A. (2019). A new heterozygous compound mutation in the CTSA gene in galactosialidosis. Human genome variation, 6(1), 1-5.

Ni, S., Weng, W., Xu, M., Wang, Q., Tan, C., Sun, H., ... & Sheng, W. (2018). miR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA. OncoTargets and therapy, 11, 3835.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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