Mouse Anti-CTNND2 Monoclonal Antibody (Y5C) (CBMAB-1008-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Rat

Clone

Y5C

Antibody Isotype

IgG1, κ

Application

IHC-P, FC, WB

Basic Information

Immunogen

Recombinant fragment, corresponding to amino acids 1081-1191 of human delta 2 Catenin

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

Introduction

Catenin delta 2 (CTNND2) is an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. CTNND2 promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. CTNND2 is associated with decreased expression of tumor suppressor E-cadherin in this tissue.

Entrez Gene ID

Human	1501
Rat	114028

UniProt ID

Human	Q9UQB3
Rat	O35116

Alternative Names

GT24; NPRAP

Function

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484).

Involved in the regulation of Wnt signaling (PubMed:25807484).

It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity).

Functions as a transcriptional activator when bound to ZBTB33 (By similarity).

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

Biological Process

Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Dendritic spine morphogenesis Source: UniProtKB
Regulation of canonical Wnt signaling pathway Source: UniProtKB
Signal transduction Source: ProtInc
Synapse organization Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Nucleus; Adherens junction; Dendrite; Perikaryon

Involvement in disease

Defects in CTNND2, including deleterious missense and copy number variants (CNVs) are involved in autism, a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

PTM

O-glycosylated.
Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).

More Infomation

References

Adegbola, A., Lutz, R., Nikkola, E., Strom, S. P., Picker, J., & Wynshaw-Boris, A. (2020). Disruption of CTNND2, encoding delta-catenin, causes a penetrant attention deficit disorder and myopia. Human Genetics and Genomics Advances, 1(1), 100007.

Stern, E. P., Guerra, S. G., Chinque, H., Acquaah, V., González-Serna, D., Ponticos, M., ... & Denton, C. P. (2020). Analysis of anti-RNA polymerase III antibody-positive systemic sclerosis and altered GPATCH2L and CTNND2 expression in scleroderma renal crisis. The Journal of Rheumatology, 47(11), 1668-1677.

Arpón, A., Santos, J. L., Milagro, F. I., Cataldo, L. R., Bravo, C., Riezu-Boj, J. I., & Martínez, J. A. (2019). Insulin sensitivity is associated with lipoprotein lipase (LPL) and catenin delta 2 (CTNND2) DNA methylation in peripheral white blood cells in non-diabetic young women. International journal of molecular sciences, 20(12), 2928.

Yang, X., Yao, B., Niu, Y., Chen, T., Mo, H., Wang, L., ... & Yao, D. (2019). Hypoxia-induced lncRNA EIF3J-AS1 accelerates hepatocellular carcinoma progression via targeting miR-122–5p/CTNND2 axis. Biochemical and Biophysical Research Communications, 518(2), 239-245.

van Rootselaar, A. F., Groffen, A. J., De Vries, B., Callenbach, P. M., Santen, G. W., Koelewijn, S., ... & Van Den Maagdenberg, A. M. (2017). δ-Catenin (CTNND2) missense mutation in familial cortical myoclonic tremor and epilepsy. Neurology, 89(23), 2341-2350.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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