Rat Anti-CTF1 Recombinant Antibody (CBXC-1354) (V2LY-0125-LY250)

Name: Rat Anti-CTF1 Recombinant Antibody (CBXC-1354)
SKU: V2LY-0125-LY250
Rating: 5 (1 reviews)

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Published Data

Rat Anti-CTF1 Recombinant Antibody (CBXC-1354) (V2LY-0125-LY250) in IHC

(a-c) Representative images of glomerular morphology assessed by PAS and haematoxylin staining in healthy mice and NTS-treated mice 7 and 21 days post-NTS administration. The arrow indicates adhesion between the glomerular tuft and the Bowman's capsule, * indicates an epithelial hyperplasia lesion. (d-f) Representative images showing immunostaining for CT-1 in healthy mice and NTS-treated mice 7 and 21 days post-NTS administration. Arrows indicate CT-1 immunostaining within the glomerular tuft and arrowheads indicate CT-1 immunostaining in the Bowman's capsule. Scale bars = 10 μm. ...View More

Perretta-Tejedor, N., Price, K. L., Jafree, D. J., Pomeranz, G., Kolatsi-Joannou, M., Martínez-Salgado, C., ... & Vasilopoulou, E. (2024). Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease. Physiological Reports, 12(13), e16129. Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBXC-1354

Antibody Isotype

IgG1

Application

WB, ELISA, IF, IHC-P

Basic Information

Immunogen

E. coli-derived recombinant mouse Cardiotrophin-1, Ser2-Ala203.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cardiotrophin 1

Entrez Gene ID

13019

UniProt ID

Q60753

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Biological Process

Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Leukemia inhibitory factor signaling pathway Source: Ensembl
Muscle organ development Source: ProtInc
Neuron development Source: Ensembl
Neuron differentiation Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of tyrosine phosphorylation of STAT protein Source: CACAO

Cellular Location

Secreted

More Infomation

References

Matokhniuk, M. O., Limanskiy, О. V., Zhebel, V. M., & Starzhynska, O. L. (2019). Cardiotrophin-1 as a marker of function and myocardial condition in essential hypertension and chronic heart failure. Reports of Vinnytsia National Medical University, 23(1), 172-177.

Lang, C., Shu, X., Peng, L., & Yu, X. (2019). The ERK signaling pathway is involved in cardiotrophin-1-induced neural differentiation of human umbilical cord blood mesenchymal stem cells in vitro. Cytotechnology, 71(5), 977-988.

Watanabe, T., Konii, H., & Sato, K. (2018). Emerging roles of cardiotrophin-1 in the pathogenesis and biomarker of atherosclerosis. J, 1(1), 94-105.

Peng, L., Shu, X., Lang, C., & Yu, X. (2017). Cardiotrophin-1 stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through PI3K/Akt-dependent signaling pathways. Cytotechnology, 69(6), 933-941.

Bortolotti, F., Ruozi, G., Falcione, A., Doimo, S., Dal Ferro, M., Lesizza, P., ... & Giacca, M. (2017). In vivo functional selection identifies cardiotrophin-1 as a cardiac engraftment factor for mesenchymal stromal cells. Circulation, 136(16), 1509-1524.

Wang, D., Liu, X., Liu, Y., Li, S., & Wang, C. (2017). The effects of cardiotrophin-1 on early synaptic mitochondrial dysfunction and synaptic pathology in APPswe/PS1dE9 mice. Journal of Alzheimer's Disease, 59(4), 1255-1267.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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