Mouse Anti-CTF1 Recombinant Antibody (CBFYC-2379) (V2LY-0125-LY247)

Name: Mouse Anti-CTF1 Recombinant Antibody (CBFYC-2379)
SKU: V2LY-0125-LY247
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBFYC-2379

Antibody Isotype

IgG2a, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Full length of human Cardiotrophin-1 (CT-1).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cardiotrophin 1

Entrez Gene ID

Human	1489
Mouse	13019
Rat	29201

UniProt ID

Human	Q16619
Mouse	Q60753
Rat	Q63086

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Biological Process

Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Leukemia inhibitory factor signaling pathway Source: Ensembl
Muscle organ development Source: ProtInc
Neuron development Source: Ensembl
Neuron differentiation Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of tyrosine phosphorylation of STAT protein Source: CACAO

Cellular Location

Secreted

More Infomation

References

Matokhniuk, M. O., Limanskiy, О. V., Zhebel, V. M., & Starzhynska, O. L. (2019). Cardiotrophin-1 as a marker of function and myocardial condition in essential hypertension and chronic heart failure. Reports of Vinnytsia National Medical University, 23(1), 172-177.

Lang, C., Shu, X., Peng, L., & Yu, X. (2019). The ERK signaling pathway is involved in cardiotrophin-1-induced neural differentiation of human umbilical cord blood mesenchymal stem cells in vitro. Cytotechnology, 71(5), 977-988.

Watanabe, T., Konii, H., & Sato, K. (2018). Emerging roles of cardiotrophin-1 in the pathogenesis and biomarker of atherosclerosis. J, 1(1), 94-105.

Peng, L., Shu, X., Lang, C., & Yu, X. (2017). Cardiotrophin-1 stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through PI3K/Akt-dependent signaling pathways. Cytotechnology, 69(6), 933-941.

Bortolotti, F., Ruozi, G., Falcione, A., Doimo, S., Dal Ferro, M., Lesizza, P., ... & Giacca, M. (2017). In vivo functional selection identifies cardiotrophin-1 as a cardiac engraftment factor for mesenchymal stromal cells. Circulation, 136(16), 1509-1524.

Wang, D., Liu, X., Liu, Y., Li, S., & Wang, C. (2017). The effects of cardiotrophin-1 on early synaptic mitochondrial dysfunction and synaptic pathology in APPswe/PS1dE9 mice. Journal of Alzheimer's Disease, 59(4), 1255-1267.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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