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Mouse Anti-CSNK2B Recombinant Antibody (260CT10.1.1) (CBMAB-1456-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
260CT10.1.1
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
CSNK2B recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Casein Kinase 2 Beta
Introduction
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. Participates in Wnt signaling (By similarity). This protein plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Entrez Gene ID
1460
UniProt ID
P67870
Alternative Names
G5A; CK2B; CK2N; Ckb1; Ckb2; CSK2B
Function
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610).

Participates in Wnt signaling (By similarity).
Biological Process
Adiponectin-activated signaling pathway Source: BHF-UCL
Cellular protein-containing complex assembly Source: BHF-UCL
Endothelial tube morphogenesis Source: BHF-UCL
Macroautophagy Source: Reactome
Mitotic chromosome condensation Source: Reactome
Negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Peptidyl-threonine phosphorylation Source: CAFA
Phosphatidylcholine biosynthetic process Source: Reactome
Positive regulation of activin receptor signaling pathway Source: BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Protein folding Source: Reactome
Regulation of DNA binding Source: BHF-UCL
Regulation of signal transduction by p53 class mediator Source: Reactome
Signal transduction Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Nucleoplasm; Nucleus; Cytoplasm; Ficolin-1-rich granule lumen; Protein kinase CK2 complex; Secretory granule lumen
Involvement in disease
Poirier-Bienvenu neurodevelopmental syndrome (POBINDS):
An autosomal dominant neurodevelopmental disorder characterized by onset of seizures in infancy, developmental delay, impaired intellectual development, and poor or absent speech.
PTM
Phosphorylated by alpha subunit.
More Infomation

Wilke, M. V., Oliveira, B. M., Pereira, A., Doriqui, M. J. R., Kok, F., & Souza, C. F. (2022). Two different presentations of de novo variants of CSNK2B: two case reports. Journal of Medical Case Reports, 16(1), 1-6.

Selvam, P., Jain, A., Cheema, A., Atwal, H., Forghani, I., & Atwal, P. S. (2021). Poirier–Bienvenu neurodevelopmental syndrome: A report of a patient with a pathogenic variant in CSNK2B with abnormal linear growth. American Journal of Medical Genetics Part A, 185(2), 539-543.

Yu, S., Hu, Q., Fan, K., Yang, C., & Gao, Y. (2021). CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling. Journal of Cell Communication and Signaling, 15(3), 383-392.

Yu, S., Li, L., Cai, H., He, B., Gao, Y., & Li, Y. (2021). Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Yang, S., Wu, L., Liao, H., Lu, X., Zhang, X., Kuang, X., & Yang, L. (2021). Clinical and genetic analysis of six Chinese children with Poirier-Bienvenu neurodevelopmental syndrome caused by CSNK2B mutation. neurogenetics, 22(4), 323-332.

Li, J., Gao, K., Cai, S., Liu, Y., Wang, Y., Huang, S., ... & Jiang, Y. (2019). Germline de novo variants in CSNK2B in Chinese patients with epilepsy. Scientific reports, 9(1), 1-8.

Nakashima, M., Tohyama, J., Nakagawa, E., Watanabe, Y., Siew, C. N. G., Kwong, C. S., ... & Matsumoto, N. (2019). Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures. Journal of human genetics, 64(4), 313-322.

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For research use only. Not intended for any clinical use.

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