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Mouse Anti-CSNK2A2 (AA 1-100) Recombinant Antibody (CBFYC-2309) (CBMAB-C2381-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2309
Antibody Isotype
IgG2a, k
Application
ELISA, IF, WB

Basic Information

Immunogen
CSNK2A2 (NP_001887.1, 1 a.a.-100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
CSNK2A2
Introduction
CSNK2A2 (Casein Kinase 2 Alpha 2) is a Protein Coding gene. Diseases associated with CSNK2A2 include Theileriasis and Spermatogenic Failure 6. Among its related pathways are Mitotic Prometaphase and Mitophagy-animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A3.
Entrez Gene ID
1459
UniProt ID
P19784
Alternative Names
Casein Kinase 2 Alpha 2; Casein Kinase 2, Alpha Prime Polypeptide; Casein Kinase 2 Alpha; CK II Alpha; EC 2.7.11.1; CK2A2
Function
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cerebral cortex development Source: Ensembl
Liver regeneration Source: Ensembl
Macroautophagy Source: Reactome
Mitotic chromosome condensation Source: Reactome
Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of ubiquitin-dependent protein catabolic process Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: ARUK-UCL
Peptidyl-threonine phosphorylation Source: GO_Central
Phosphatidylcholine biosynthetic process Source: Reactome
Positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Protein folding Source: Reactome
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of cell cycle Source: GO_Central
Regulation of chromosome separation Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Spermatogenesis Source: Ensembl
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytosol; Nucleoplasm; Nucleus; Plasma membrane; Acrosomal vesicle; Chromatin; Protein kinase CK2 complex
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For research use only. Not intended for any clinical use.

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