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Mouse Anti-CREB3L4 Antibody (1A3) (CBMAB-0241-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A3
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CAMP Responsive Element Binding Protein 3 Like 4
Introduction
CREB3L4 (cAMP responsive element binding protein 3 like 4) is a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. It is a transcriptional activator which contains a dimerization domain, and may function in a number of processing pathways including protein processing.
Entrez Gene ID
148327
UniProt ID
Q8TEY5
Alternative Names
CAMP Responsive Element Binding Protein 3-Like 4; CAMP-Responsive Element-Binding Protein 3-Like Protein 4; Cyclic AMP-Responsive Element-Binding Protein 4; Transcript Induced In Spermiogenesis Protein 40; Androgen-Induced Basic Leucine Zipper Protein; CAMP-Responsive Element-Binding Protein 4; Attaching To CRE-Like 1; Tisp40; AIBZIP; CREB-4; ATCE1; CREB4; HJAL; JAL; CAMP Responsive Element Binding Protein 1; CREB3
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Biological Process
Endoplasmic reticulum unfolded protein response Source: InterPro
Positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane. May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Topology
Cytoplasmic: 1-295
Helical: 296-316
Lumenal: 317-395
PTM
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
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For research use only. Not intended for any clinical use.

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