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Mouse Anti-CR2 Recombinant Antibody (CBFYC-2180) (V2LY-1206-LY1054)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-2180
Antibody Isotype
IgG1
Application
ELISA, IHC

Basic Information

Immunogen
Human CD21
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Complement C3d Receptor 2
Entrez Gene ID
Human1380
Mouse12902
Rat289395
UniProt ID
HumanP20023
MouseP19070
RatA6JH50
Alternative Names
Complement C3d Receptor 2; Complement Component (3d/Epstein Barr Virus) Receptor 2; Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor; EBV Receptor; C3DR; Complement Receptor Type 2; Complement C3d Receptor;
Function
Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047).

Participates in B lymphocytes activation (PubMed:7753047).

(Microbial infection) Acts as a receptor for Epstein-Barr virus.
Biological Process
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
Complement activation, alternative pathway Source: ARUK-UCL
Complement activation, classical pathway Source: UniProtKB-KW
Immune response Source: UniProtKB
Regulation of complement activation Source: Reactome
Cellular Location
Cell membrane
Involvement in disease
Systemic lupus erythematosus 9 (SLEB9):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Immunodeficiency, common variable, 7 (CVID7):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 21-971
Helical: 972-999
Cytoplasmic: 1000-1033
More Infomation

Erdei, A., Kovács, K. G., Nagy-Baló, Z., Lukácsi, S., Mácsik-Valent, B., Kurucz, I., & Bajtay, Z. (2021). New aspects in the regulation of human B cell functions by complement receptors CR1, CR2, CR3 and CR4. Immunology Letters, 237, 42-57.

Kovács, K. G., Mácsik-Valent, B., Matkó, J., Bajtay, Z., & Erdei, A. (2021). Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells. Frontiers in immunology, 12.

Ng, H. L., Taylor, R. L., Cheng, J., Abraham, L. J., Quail, E., Cruickshank, M. N., & Ulgiati, D. (2020). Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model. Molecular Immunology, 128, 150-164.

Meza, G., Expósito, A., Royo, J. L., Ruiz-García, C., Sánchez-Arcas, B., Marquez, F. J., ... & Caruz, A. (2020). Association of Complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 Vaccine. AIDS, 34(1), 25-32.

Halkjær, L., Troldborg, A., Pedersen, H., Jensen, L., Hansen, A. G., Hansen, T. K., ... & Thiel, S. (2020). Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans. Frontiers in immunology, 11, 774.

Smith, N. A., Coleman, C. B., Gewurz, B. E., & Rochford, R. (2020). CD21 (Complement Receptor 2) is the receptor for Epstein-Barr virus entry into T cells. Journal of virology, 94(11), e00428-20.

Pekalski, M. L., García, A. R., Ferreira, R. C., Rainbow, D. B., Smyth, D. J., Mashar, M., ... & Wicker, L. S. (2017). Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2. JCI insight, 2(16).

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For research use only. Not intended for any clinical use.

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