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Mouse Anti-CPNE6 Recombinant Antibody (CBXC-0538) (V2LY-1206-LY973)


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Published Data
V2LY-1206-LY973-1
Mouse Anti-CPNE6 Recombinant Antibody (CBXC-0538) (V2LY-1206-LY973) in WB
Western blot analysis of hippocampal lysates of mice of indicated age. β-actin was used as loading control. ...View More
Reinhard, J. R., Kriz, A., Galic, M., Angliker, N., Rajalu, M., Vogt, K. E., & Ruegg, M. A. (2016). The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature communications, 7(1), 11613.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY973-2
Mouse Anti-CPNE6 Recombinant Antibody (CBXC-0538) (V2LY-1206-LY973) in IF
Time-lapse confocal pictures of DIV14 hippocampal neurons expressing Copine-6-GFP (green) and cytosolic tdRFP (red) during stimulation with 10 μM NMDA. Time points indicate minutes after NMDA application. Scale bar, 20 μm. ...View More
Reinhard, J. R., Kriz, A., Galic, M., Angliker, N., Rajalu, M., Vogt, K. E., & Ruegg, M. A. (2016). The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature communications, 7(1), 11613.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-0538
Antibody Isotype
IgG1, κ
Application
WB, IP, IF

Basic Information

Immunogen
Amino acids 4-125 of mouse copine 6.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
copine VI (neuronal)
Entrez Gene ID
Human9362
Mouse12891
Rat691478
UniProt ID
HumanO95741
MouseQ9Z140
RatD4ACG7
Function
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Cell differentiation Source: UniProtKB-KW
Cellular response to calcium ion Source: GO_Central
Chemical synaptic transmission Source: ProtInc
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Positive regulation of dendrite extension Source: UniProtKB
Vesicle-mediated transport Source: ProtInc
Cellular Location
Endosome; Cell membrane; Cytoplasm; Clathrin-coated vesicle; Perikaryon; Dendrite. Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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