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Mouse Anti-COPS3 Recombinant Antibody (10B2309) (CBMAB-C2189-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2309
Antibody Isotype
IgG2a
Application
ELISA, IHC-F, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COPS3
Introduction
COPS3 (COP9 Signalosome Subunit 3) is a Protein Coding gene. Diseases associated with COPS3 include Smith-Magenis Syndrome and Osteogenic Sarcoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport.
Entrez Gene ID
8533
UniProt ID
Q9UNS2
Alternative Names
COP9 Signalosome Subunit 3; JAB1-Containing Signalosome Subunit 3; Signalosome Subunit 3; CSN3; SGN3; COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 3;
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Biological Process
In utero embryonic development Source: Ensembl
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Response to light stimulus Source: ProtInc
Signal transduction Source: ProtInc
Transcription-coupled nucleotide-excision repair Source: Reactome
Ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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