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Mouse Anti-COMMD3 Recombinant Antibody (2E2) (CBMAB-C4981-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E2
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF

Basic Information

Immunogen
COMMD3 (AAH22898, 1 a.a. ~ 195 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2-1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COMM domain containing 3
Introduction
COMMD3 (COMM Domain Containing 3) is a Protein Coding gene. Among its related pathways are Innate Immune System.
Entrez Gene ID
23412
UniProt ID
Q9UBI1
Alternative Names
COMM Domain Containing 3; Protein Bup; C10orf8; BUP; Chromosome 10 Open Reading Frame 8; COMM Domain-Containing Protein 3; Protein PIL;
Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237).

May down-regulate activation of NF-kappa-B (PubMed:15799966).

Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Biological Process
Neutrophil degranulation Source: Reactome
Sodium ion transport Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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