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Mouse Anti-COIL Recombinant Antibody (CBFYC-2032) (V2LY-1206-LY583)


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Published Data
V2LY-1206-LY583-1
Mouse Anti-COIL Recombinant Antibody (CBFYC-2032) (V2LY-1206-LY583) in IF
HCT116-PSMB2-EGFP cells under hyperosmotic stress were immunostained with coilin (a marker for Cajal bodies) and promyelocytic leukemia proteins (for PML bodies). ...View More
Lee, J., Le, L. T. H. L., Kim, E., & Lee, M. J. (2021). Formation of non-nucleoplasmic proteasome foci during the late stage of hyperosmotic stress. Cells, 10(9), 2493.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY583-2
Mouse Anti-COIL Recombinant Antibody (CBFYC-2032) (V2LY-1206-LY583) in IF
Immunofluorescent detection of the GFP-tagged WRAP53β proteins indicated in HeLa cells 24 h post-transfection. The Cajal bodies were visualized by immunostaining for coilin and nuclei stained blue with DAPI in all cases. ...View More
Bergstrand, S., Böhm, S., Malmgren, H., Norberg, A., Sundin, M., Nordgren, A., & Farnebo, M. (2020). Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. Cell death & disease, 11(4), 238.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2032
Antibody Isotype
IgG1
Application
WB, IP, IF

Basic Information

Immunogen
C-terminus of coilin of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coilin
Entrez Gene ID
8161
UniProt ID
P38432
Function
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Biological Process
Spliceosomal snRNP assembly Source: GO_Central
Cellular Location
Nucleus; Cajal body
PTM
Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylation during mitosis is associated with disassembly of CBs.
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For research use only. Not intended for any clinical use.

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