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Rabbit Anti-CNTN2 Recombinant Antibody (EG755) (CBMAB-EN910-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG755
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CNTN2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Contactin 2
Introduction
CNTN2 (Contactin 2) is a Protein Coding gene. Diseases associated with CNTN2 include Epilepsy, Familial Adult Myoclonic, 5 and Benign Adult Familial Myoclonic Epilepsy. Among its related pathways are L1CAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CNTN1.
Entrez Gene ID
Human6900
Mouse21367
Rat25356
UniProt ID
HumanQ02246
MouseQ61330
RatP22063
Alternative Names
Contactin 2; Transient Axonal Glycoprotein 1; Axonal Glycoprotein TAG-1; Contactin 2 (Axonal); TAX1; AXT; Contactin 2 (Transiently Expressed); Axonin-1 Cell Adhesion Molecule;
Function
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
Biological Process
Axon guidance Source: GO_Central
Cell adhesion Source: ProtInc
Clustering of voltage-gated potassium channels Source: BHF-UCL
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Presynaptic membrane organization Source: UniProtKB
Protein localization to juxtaparanode region of axon Source: BHF-UCL
Cellular Location
Cell membrane. Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
Involvement in disease
Epilepsy, familial adult myoclonic, 5 (FAME5):
A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME5 is characterized by onset of seizures in adolescence, followed by the development of cortical myoclonic tremor later in life. Inheritance is autosomal recessive.
More Infomation

Savvaki, M., Kafetzis, G., Kaplanis, S. I., Ktena, N., Theodorakis, K., & Karagogeos, D. (2021). Neuronal, but not glial, Contactin 2 negatively regulates axon regeneration in the injured adult optic nerve. European Journal of Neuroscience, 53(6), 1705-1721.

Kalafatakis, I., Kalafatakis, K., Tsimpolis, A., Giannakeas, N., Tsipouras, M., Tzallas, A., & Karagogeos, D. (2020). Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2. Brain Structure and Function, 225(7), 2045-2056.

Marell, P. S., Blohowiak, S. E., Evans, M. D., Georgieff, M. K., Kling, P. J., & Tran, P. V. (2019). Cord blood-derived exosomal CNTN2 and BDNF: potential molecular markers for brain health of neonates at risk for iron deficiency. Nutrients, 11(10), 2478.

Zoupi, L., Savvaki, M., Kalemaki, K., Kalafatakis, I., Sidiropoulou, K., & Karagogeos, D. (2018). The function of contactin‐2/TAG‐1 in oligodendrocytes in health and demyelinating pathology. Glia, 66(3), 576-591.

Wang, P., He, J., Wang, S., Wang, X., Liu, Q., Peng, W., & Qian, T. (2018). miR-3075 inhibited the migration of Schwann cells by targeting Cntn2. Neurochemical Research, 43(10), 1879-1886.

Guo, Y., Zhang, P., Zhang, H., Zhang, P., & Xu, R. (2017). RNAi for contactin 2 inhibits proliferation of U87-glioma stem cells by downregulating AICD, EGFR, and HES1. OncoTargets and therapy, 10, 791.

Gandomi, N., Varshochian, R., Atyabi, F., Ghahremani, M. H., Sharifzadeh, M., Amini, M., & Dinarvand, R. (2017). Solid lipid nanoparticles surface modified with anti-Contactin-2 or anti-Neurofascin for brain-targeted delivery of medicines. Pharmaceutical Development and Technology, 22(3), 426-435.

Masuda, T. (2017). Contactin-2/TAG-1, active on the front line for three decades. Cell adhesion & migration, 11(5-6), 524-531.

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For research use only. Not intended for any clinical use.

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